犬阵发性房颤转复窦律后时间依赖性心房电逆重构的研究  

A study of time-dependent reversal electrophysiological remodeling on atrium after paroxysmal atrial fibrillation converted to sinus rhythm in canine model

作　　者：张彦[1] 于付生[1] 冯艳[1] 张玲[1] 宋伟[1] 马艳红[1] 侯月梅[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,心律失常VIP实验室,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2010年第1期1-3,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30760079)

摘　　要：目的探讨犬阵发性房颤转复期间时间依赖性心房电逆重构情况。方法健康成年杂种犬18只,随机分为快速起搏组(n=10,ATP组)和假手术组(n=8,Sham组)。分别于快速右心房起搏48h及转复24h期间,在0、48(起搏停止)、52、56、60、64、68、72h电生理检测高右房(HRA)的有效不应期(ERP)、传导速度(CV)、折返波长(WL)、频率自适应性、房颤诱发率等反映心房电生理特性的指标。结果起博48h后,ATP组ERP、CV、WL较Sham组减少,ATP组频率自适应性较Sham组降低(P<0.05),房颤诱发率明显增加。停止起搏24h后ERP、FA、房颤诱发率与Sham组及起搏前相比差异无统计学意义(P>0.05);CV与Sham组及起搏前相比差异有统计学意义(P<0.05)。结论犬48h快速心房起搏所致左、右心房电重构在转复24h后,ERP、FA、房颤诱发率发生逆转,但CV、WL仍不能逆转。Objective To examine the reversibility of the changes in electrophysiological remodeling on atrium in dogs with paroxysmal atrial fibrillation. Methods Eighteen adult mongel dogs were randomly divided into 2 groups, atrail tachypacing group （n = 10） and sham group （n =8）. The parameters reflecting the changes of atrial electrophysiological properties were observed, including effective refractory period （ERP） of high right atria, conduction velocity （CV）, wave length （WL）, adaptation of ERP, inducibility of atrial fibrillation at 0, 48, 52, 60, 66, 72 h. Results After pacing 48 h. The ERP, CV, WL of the ATP group was less than those of the sham group. The frequence self-adaptatibiliy of the ATP group was less than those of the sham group （P〈0.05）, the inducibility of atrial fibrillation obviously incresed. After stop ping pacing 48 h, the difference of ERP, FA, the inducbility of atrial fibrillation compared with sham group and pace before with no statistic significance （P〉0.05）. There was statistic significance about CV between sham group and pacing before. Conclusion Electrophysiological remodeling can be partially reversed after AF converted to sinus rhythm 24 hours. ERP, FA, inducibility of atrial fibrillation can be reversed, CV, WL still can＇t be reversed.

关 键 词：心房颤动 犬 电重构 转复 

分 类 号：R541.7[医药卫生—心血管疾病]