类固醇激素与中心性肥胖  

Steroid Hormone and Central Obesity

作　　者：张丽[1] 李晓南[1] 

机构地区：[1]南京医科大学附属南京儿童医院儿童保健科,南京210029

出　　处：《医学综述》2010年第7期961-964,共4页Medical Recapitulate

基　　金：国家自然科学基金(30672269)

摘　　要：脂肪组织尤其是内脏脂肪的积聚与中心性肥胖及代谢综合征密切相关,而体内脂肪组织的分布受到糖皮质激素、雌激素和雄激素等类固醇激素影响。这些激素可能通过部位特异性受体分布、脂肪细胞增殖分化及脂肪细胞因子分泌的调控,影响人体脂肪组织的积聚和分布。循环中或组织局部的糖皮质激素、雌激素和雄激素可能通过调控糖脂代谢,参与代谢综合征产生。The accumulation of adipose tissue, especially visceral adipose tissue is associated with metabolic syndrome and central obesity. Glucocorticoid, estrogens and androgen can regulate body fat distribution patterns. It is reported that glucocorticoid,estrogens and androgens can regulate human adipose tissue accumulation and distribution site-differently through combining receptor,regulating cytokines and cell differentiation or proliferation. The level of glucocorticoid, estrogens and androgen in circulation and tissue involve in the development of metabolic syndrome by regulating glucose or lipid metabolism.

关 键 词：糖皮质激素 雌激素 雄激素 中心性肥胖 

分 类 号：R392.5[医药卫生—免疫学] R392.6[医药卫生—基础医学]