血红蛋白抗大鼠大肠埃希菌阴道感染研究  

Effect of hemoglobin on E.coli vaginal infection in rats

作　　者：周新娥[1,2] 欧阳运薇[3] 潘小玲[3] 何跃东[3] 李恒[2] 邓璐霞[2] 黄宁[2] 吴琦[2] 

机构地区：[1]成都市妇产科医院妇产科,成都610015 [2]四川大学华西基础医学与法医学院感染免疫教研室,成都610041 [3]四川大学华西第二医院妇产科,成都610041

出　　处：《四川生理科学杂志》2010年第1期1-3,共3页Sichuan Journal of Physiological Sciences

基　　金：CMB基金(编号:98-681);自然科学基金(编号:No.30470763;30470763)

摘　　要：目的:探讨血红蛋白在大鼠体内是否具有抗菌抑炎作用。方法:构建大鼠阴道感染模型后随机设立实验组和对照组,阴道给予血红蛋白后观察子宫宫颈阴道脏器指数,并采用组织病理切片检测血红蛋白治疗前后各组指标变化。结果:子宫宫颈阴道脏器指数经统计学分析示血红蛋白组、模型对照组间无差异(P>0.05),基质对照组与前两组比均有显著性差异(P<0.05),基质对照组的脏器指数增加明显。结论:血红蛋白能减轻大鼠大肠埃希菌阴道感染炎症病变程度。Objective： To detect the effect of hemoglobin on E. coli vaginal infection in rats. Methods： After establishing rat model of persistent vaginal infection with E. coli , the rats were randomized into the experimental group and the control group. The experimental group was administered intravaginally with hemoglobin. The histologically pathological section and the organ index of uterine and vagina were observed, then the indicator changes of each group before and after treatment were analyzed. Results： With statistical analysis of the organ index of rat uterine cervix and vagina, there were no difference between the hemoglobin group （the experimental group） and the control group （P〉0. 05）. The comparison between the matrix control group （no treatment after infection） with the former two groups, there was significant difference （P〈0.05）. The organ index of the matrix control group increased significant. Conclusion： Hemoglobin might relieve the inflammation of E. coli vaginal infection in rats.

关 键 词：血红蛋白 抗菌抑炎 大肠埃希菌性阴道炎 

分 类 号：R711.3[医药卫生—妇产科学]