干细胞不对称分裂模式与肿瘤发生  

Advance in Asymmetric Divisions of Stem Cells and Tumorigenesis

作　　者：钱伶凌[1] 陈晓萍[1] 顾娟[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,浙江杭州310014

出　　处：《生物技术通讯》2010年第2期266-269,共4页Letters in Biotechnology

基　　金：国家自然科学基金(30972446)

摘　　要：干细胞发育中存在对称/不对称两种方式的交替分裂,精确调控维持正常发育。相关调控因素有外源性机制和内源性机制,发现于基本模式生物果蝇,主要包括干细胞周围微环境、细胞极性、纺锤体轴向和命运决定子不对称分布。调控机制的失常将导致干细胞分裂模式紊乱,可能造成肿瘤发生。简要综述了相关研究进展。Alternation of two division ways,symmetric division and asymmetric division,exists in the procession of stem cells.The normal ontogenisis depends on the accurately regulation by extrinsic and intrinsic regulation mechanism which discovered in standard animal Drosophila.The relative factors include stem cell niche,cellular polarity,spindle orientation and cell fate determinants.Abnormal in these mechanism will disorder the division models and may induce cancer.This article maked a summarize of the related research progression.

关 键 词：干细胞 不对称分裂 肿瘤发生 

分 类 号：Q26[生物学—细胞生物学] Q25