肾小球滤过率估测值评判老年高血压及2型糖尿病并发终末期肾病患者血红蛋白浓度的变化  

Study of change of plasma hemoglobin concentration in elderly patients with primary hypertension and/or type 2 diabetes complicated with end-stage renal disease determined by estimated glomerular filtration rate

作　　者：巩玲俊[1] 李刚[2] 牟杨[2] 朱炳豹[2] 

机构地区：[1]宁波市李惠利医院干部病房 [2]重庆医科大学附属第一医院老年科心血管病组,重庆400016

出　　处：《中国老年学杂志》2010年第5期577-579,共3页Chinese Journal of Gerontology

基　　金：重庆市科委自然科学基金计划资助项目〔渝科发计字(2007)25号CSTC,2007BB5276〕;重庆市卫生局医学科学技术研究项目〔渝卫教2004(53)04-2-154,2009-2-290〕

摘　　要：目的探讨用肾小球滤过率估测值(eGFR)评判的老年高血压及2型糖尿病并发终末期肾病(ESRD)患者血红蛋白(Hb)浓度改变。方法收集高血压及2型糖尿病并发慢性肾病且≥60岁患者230例,将eGFR<15ml.min-1.1.73m-2(7.80±3.14ml.min-1.1.73m-2)者归为ESRD组,eGFR≥15ml.min-1.1.73m-2(29.76±12.90ml.min-1.1.73m-2)者归为非ESRD组,回顾性比较两组间Hb浓度。结果较非ESRD组〔Hb(100.8±23.0)g/L〕,ESRD组Hb浓度〔(74.4±22.5)g/L〕显著降低(P<0.05),且在ESRD与非ESRD组中eGFR均与Hb浓度显著正相关(P<0.05)。结论eGFR评判的老年高血压及2型糖尿病并发ESRD患者Hb浓度显著降低,且eGFR与Hb浓度具有显著正相关性。Objective To study the change of plasma hemoglobin（Hb） concentration in elderly patients with primary hypertension and/or type 2 diabetes （T2DM） complicated with end-stage renal disease（ESRD） determined by estimated glomerular filtration rate（eGFR）.Methods Two hundred thirty cases of patients aged 60 years or older with primary hypertension and/or T2DM complicated with chronic renal disease were enrolled.Patients with chronic renal disease were divided into ESRD group with eGFR less than 15 ml·min-1·1.73 m-2 （7.80±3.14 ml·min-1·1.73 m-2）and non-ESRD group with eGFR not less than 15 ml·min-1·1.73 m-2 〔（29.76±12.90） ml·min-1·1.73 m-2〕.Hb concentration was compared between the above two groups retrospectively.Results Compared with non-ESRD group〔（Hb 100.8 ± 23.0）g/L〕 there was significant decrease in Hb concentration 〔（74.4 ± 22.5）g/L〕 in ESRD group（P0.05）;eGFR was positively related to Hb concentration in ESRD and non-ESRD groups respectively（P0.05,for both）.Conclusions There is significant decrease in Hb concentration in elderly patients with primary hypertension and/or T2DM complicated with ESRD determined by eGFR;eGFR is significantly positively related to Hb concentration.

关 键 词：高血压 2型糖尿病 终末期肾病 肾小球滤过率 血红蛋白浓度 

分 类 号：R541.3[医药卫生—心血管疾病] R589.1[医药卫生—内科学]