肾源性系统性纤维化  

Nephrogenic systemic fibrosis

作　　者：安晓静[1] 刘冲[1] 石群立[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)病理科,南京医学硕士研究生210002

出　　处：《医学研究生学报》2010年第3期311-314,共4页Journal of Medical Postgraduates

基　　金：南京军区医学科学技术研究"十一五"计划课题(06Z37)

摘　　要：肾源性系统性硬化症(nephrogenic systemic fibrosis,NSF)是发生在肾功能不全患者因注射MRI造影剂而引发的系统性硬化症,累及全身多个器官,但以下肢为首发。初发症状为皮肤红斑、僵硬,病情进展累及全身多个器官,最终因器官衰竭而死亡。皮肤活检示真皮层内大量胶原和纤维组织增生,确诊需结合临床病史与组织病理学综合考虑。其发生机制,目前还无较明确而有力的证实。文中就该病的流行病学特征、临床病理特点及免疫表型、发生机制等进行综述。Nephrogenic systemic fibrosis occurs on patients with the renal function disorder,who were injected gadolinium-containing MRI contrast agents.It is a systemic disease,usually involved with low limbs firstly,and then other organs.Patients often complained of erythema and wood-feeling on skin and finally died of the failure of organs.Histopathologically,a number of collagen and fibrosis was seen in the dermis.The diagnosis depends on clinical history and pathology.However,the mechanism is unclear.In this paper,we make a review about NSF.

关 键 词：肾源性系统性纤维化 造影剂 

分 类 号：R814.43[医药卫生—影像医学与核医学]