运动加一氧化氮供体治疗去卵巢大鼠骨质疏松的实验研究  

The study of therapeutic effects of training plus Nitric Oxide Donor on osteoporosis in ovariectomized rats

作　　者：王广斌[1] 刘忠厚 王佳时[1] 贺明[1] 付勤[1] 

机构地区：[1]中国医科大学附属盛京医院骨外科,沈阳110004 [2]中国老年学会骨质疏松委员会

出　　处：《中国骨质疏松杂志》2010年第3期188-193,共6页Chinese Journal of Osteoporosis

摘　　要：目的观察运动加一氧化氮供体左旋精氨酸(L-Arg)对去卵巢大鼠的影响。方法60只SD雌性大鼠,随机分成六组:正常对照组(SHAM)、去卵巢手术组(OVX)、雌激素对照组(OVX+ES)、运动组(OVX+ET)、左旋精氨酸组(OVX+L-Arg)、运动+左旋精氨酸组(OVX+ET+L-Arg),每组10只,12周后进行骨密度、生物力学以及骨代谢指标测定。结果运动+L-Arg组的大鼠的体重在各实验组中最接近正常对照组;运动+L-Arg组的大鼠全身和腰椎部以及股骨的骨密度提高非常明显,是各组中最高的;经单纯运动、单纯L-Arg以及运动+L-Arg治疗后的去卵巢大鼠的股骨部位的骨矿含量(BMC)有显著提高。结论运动+左旋精氨酸是一种安全、可靠、实用、有效的骨质疏松的防治方法,值得推广。Objective To observe the effect of training plus Nitric Oxide Donor on the ovariectomized rats. Methods 60 six-month-old SD female rats were randomly assigned to six groups：normal supplement group （ SHAM）, ovariectomized group （ OVX ）, estrogen supplementgroup （ OVX ＋ ES ）, training group （ OVX ＋ ET）, Nitric Oxide Donor group（ OVX ＋ L-arg）, training plus Nitric Oxide Donor group（ OVX ＋ ET ＋ L- arg）. After 12weeks,bone mineral density, biomeehanics of bone and the markers of bone metabolism were measured. Results The body weight of rat in the OVX ＋ ET ＋ L-arg group was most close to the sham group compared with the other groups,The BMD in the OVX ＋ ET ＋ L-arg group increased in whole body and lumbar vertebrace and femur compared with the OVX group, In femur, the BMC of ovariectomized rat was increased remarkably by therapy of exercise training, L-arg and exercise training plus L-arg. Conclusion Training plus L-arg is a safe and effective method in prevention of osteoporosis and it is worth to be extended.

关 键 词：骨质疏松 运动 一氧化氮供体 左旋精氨酸 

分 类 号：Q813[生物学—生物工程] R329[医药卫生—人体解剖和组织胚胎学]