心肌梗死患者CD4^+CD25^+Foxp3^+ T细胞检测及意义  

Significance of the change of CD4^+CD25^+ Foxp3^+ regulation T cells in patients with myocardial infarction

作　　者：贺慧娟[1] 吴海[1] 廖钦晨[1] 陈世德[1] 闭奇[1] 

机构地区：[1]广西医科大学第一附属医院心血管内科,南宁市530021

出　　处：《内科》2010年第1期1-3,共3页Internal Medicine

基　　金：广西自然科学基金资助(0640108)

摘　　要：目的探讨心肌梗死患者外周血CD4+CD25+Foxp3+T细胞的水平及意义。方法采用流式细胞分析法,检测20例急性心肌梗死患者(AMI组)、21例陈旧性心肌梗死患者(OMI组)和36例健康体检者(对照组)外周血CD4+CD25+Foxp3+T细胞水平。结果 AMI组、OMI组的CD4+CD25+T细胞/CD4+T细胞比例分别为(7.20±1.96)%和(7.55±1.77)%均低于对照组的(8.81±1.50)%(P<0.05);CD4+CD25+Foxp3+T细胞/CD4+T细胞比例AMI组为(1.42±0.38)%和OMI组为(1.46±0.55)%均比对照组(1.75±0.58)%低(P<0.05)。结论 CD4+CD25+调节性T细胞比例降低可能打破了外周免疫耐受,参与了心肌梗死患者动脉粥样硬化的发生发展。Objective To explore the significance of the change of CD4 ＋ CD25 ＋ Foxp3 ＋ regulation T ceils in peripheral blood of patients with myocardial infarction. Methods The proportion of CD4 ＋ CD25 ＋ Foxp3 ＋ T cells were detected in 20 patients with acute myocardial infarction （AMI group）, 21 patients with old myocardial infarction （OMI group） and 36 healthy individuals （ control group） by flow cytometry. Results CD4 ＋ CD25 ＋ T cells/CD4 ＋ T cells in both AMI group（7.06 ± 2.15 ） % and OMI group （7.55± 1.77 ） % were significantly lower than in control group（ 8.81 ± 1.50） % （ P 〈 0.05 ）. Moreover CD4 ＋ CD25 ＋ Foxp3 ＋ cells / CD4 ＋ T cells in both AMI group （ 1.43 ± 0.48 ） % and OMI group （ 1.46 ± 0.55 ） % were significantly lower than in control group （ 1.75 ± 0.58） % （ P 〈 0.05 ）. Conclusion Reduction of CD4＋ CD25 ＋ regulation T cells may lead to the breakdown of peripheral autoimmune tolerance and participate in the progression of atheroselerosis and myocardial infarction.

关 键 词：心肌梗死 CD4+CD25+Foxp3+ 调节性T细胞 动脉粥样硬化 

分 类 号：R542.22[医药卫生—心血管疾病]