家族史与儿童青少年血脂紊乱关系的研究  

Relationship between family history and dyslipidemia in children

作　　者：闫辉[1] 米杰[2] 刘颖[1] 程红[2] 陈建军[1] 张秀芝[1] 杜军保[1] 

机构地区：[1]北京大学第一医院儿科,北京100034 [2]首都儿科研究所流行病研究室.北京100020

出　　处：《中国实用儿科杂志》2010年第3期195-198,共4页Chinese Journal of Practical Pediatrics

基　　金：北京市科技计划项目(H030930030530);国家重点基础研究发展计划(973)项目(2006CB503807)

摘　　要：目的探讨家族史与儿童血脂水平的关系。方法2004年4月至10月"营养转型期儿童、成人慢性病综合性防治研究"课题组采用整群抽样方法对北京地区6～18岁儿童青少年进行横断面流行病学调查。有效调查对象19306名,其中男9665名,女9641名;按年龄及性别分为男性学龄期组、青春期组,女性学龄期组、青春期组。根据家族史背景分为无家族史、有一级家族史、有二级家族史。对其空腹末梢血总胆固醇(TC)、三酰甘油(甘油三酯TG)进行检测。结果有一级家族史者,各年龄段男童组TC及TG水平均显著高于无家族史者(P<0.05),学龄期女性儿童组TC显著高于无家族史者([4.07±0.41)mmo/L、(4.00±0.33)mmo/L,P<0.05],青春期女性儿童组TG显著高于无家族史者([1.26±0.75)mmo/L、(1.20±0.66)mmo/L,P<0.05];有二级家族史者,各年龄阶段男性儿童组TC及TG均显著高于无家族史者(P<0.05),各年龄组女性儿童TC均显著高于无家族史者(P<0.05)。将肥胖作为混杂因素行协方差分析后,有不同家族史背景的各年龄性别分组儿童TC水平差异仍有统计学意义(P<0.05)。学龄期男性儿童组、青春期男性儿童组及学龄期女性儿童组有一级家族史者血脂紊乱的发生率均显著高于非一级家族史者(11.6%、7.1%,11.2%、8.4%,10.8%、8.0%,P<0.05),有二级家族史青春期男性儿童组及青春期女性儿童组血脂紊乱的发生率显著高于无家族史者(10.3%、7.8%,14.7%、11.8%,P<0.05)。结论不同家族史背景儿童血脂水平差异有统计学意义,一级及二级家族史在儿童血脂紊乱筛查中具有一定意义。Objective To investigate the relationship between family history and dyslipidemia in children. Methods This study was performed by research group on adult chronic diseases prevention and therapy in children.Cluster randomized sampling in a transecting epidemiologic, al survey of children aged 6 to 18 years in Beijing area were used; 9665 boys and 9641 girls were virtually included in the study. They were divided into four subgroups, including school boys, school girls, adolescent boys and adolescent girls. Parent history of metabolic syndrome and premature cardiovascular diseases were defined as first degree family history, grandparent or/and uncle/aunt history of metabolic syndrome and cardiovascular diseases were defined as second degree family history, while others were defined as without family histo- ry. Fasting capillary blood total cholesterol （TC） and triglyceride （TG） levels were detected. Results TC and TG levels of school boys and adolescent boys with first degree family history were all much higher than boys without family history （4.07±0.41 ） mmo/L vs （4.00±0.33） mmo/L, P 〈 0.05 ; TG of adolescent girls was significantly higher than girls without family history （ 1.26±0.75 ） mmo/L vs （ 1.20±0.66 ） mmo/L, P 〈 0.05. TC and TG levels of school boys and adolescent boys with second degree family history were all much higher than boys without family history （P 〈 0.05 ） ; TC levels of school girls and adolescent girls with second degree family history were all much higher than girls without family histo-ry （P 〈 0.05）. Possibility of dyslipidemia of school and adolescent boys and school girls with first degree family history was much higher than those with nonfirst degree family history（11.6 %vs 7.1%, 11.2 %vs 8.4%, 10.8% vs 8.0%, P 〈 0.05）. Possibility of dyslipidemia of adoles-cent boys and girls with second degree family history, were significantly higher than those without family history （ 10.3% vs 7.8%, 14.7% vs 11.8%, P 〈 0.05）. Conclusion The lip

关 键 词：儿童 血脂紊乱 家族史 

分 类 号：R72[医药卫生—儿科]