犬腹腔镜下胸腔和腹腔通路膈肌破裂修补术对肝肾功能的影响  

Effect of laparoscopic repair of diaphragmatic rupture through thoracic and celiac path on hepatic and renal function in dogs

作　　者：张楠[1] 张建涛[1] 张士霞[1] 石焦[1] 王洪斌[1] 

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030

出　　处：《东北农业大学学报》2010年第3期109-113,共5页Journal of Northeast Agricultural University

基　　金：黑龙江省龙江学者奖励计划项目资助

摘　　要：为了解腹腔镜手术对犬肝肾功能变化的影响以及探讨其可能的发生机制。12只健康杂种犬随机均分为两组:胸腔通路腹腔镜膈肌破裂修补术(LDT)和腹腔通路腹腔镜膈肌破裂修补术(LDC)。在术前、术后即刻、1、3、5、7 d采集血清样品进行肝肾功能的检测。结果表明,LDT、LDC两组的血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、肌酐(Cr)、尿素(BUN)与术前比较,都有显著性差异(P<0.05)。与LDT组比较,LDC组ALT在术后即刻与第3天均有极显著性差异(P<0.01),AST在术后即刻与第1、3天比较均有极显著性差异(P<0.01)。同时也对其他肝肾功能指标进行了检测与数据处理,未发现有意义的改变。LDT和LDC可导致血清肝脏、肾脏酶学有统计学意义的短暂增高。LDC较LDT对ALT与AST影响更显著。Investigate the effect of laparoseopic surgery on the change of hepatic and renal function of dogs, and explore their possible mechanism. Twelve healthy mongrel dogs were randomly divided into two groups： Laparoscopic repair of diaphragmatic rupture through thoracic path in dogs （LDT） and Laparoscopic repair of diaphragmatic rupture through celiac path in dogs （LDC）. The venous blood samples were obtained at the time of the preoperative day and immediately, I, 3, 5, 7 d after operations. The results showed that alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, alkaline pho- sphatase （ALP）, creatinine （Cr） and blood urea nitrogen （BUN） in group LDT and LDC were significantly increased after operation.These changes occurred in each group that had demonstrated remarkable difference before and after the operation （P〈0.05）. The degree in the changes of ALT between LDC and LDT was significant （P〈0.01） on immediately and 3 d after operations. The differences between LDT and LDC also show significance （P〈0.01） on immediately and 1, 3 d after operations. In the mean time, changes of ALP, Cr and BUN before or after surgery in both groups showed no significant difference （P〉0.05）. Transient elevation of serum liver and renal enzymes can step-up after LDT and LDC on short term. Compared with LDT, the degree in the changes of ALT and AST in LDC was more significant.

关 键 词：腹腔镜 膈肌破裂 犬 肝功能 肾功能 

分 类 号：S829.2[农业科学—畜牧学]