巨大脑动静脉畸形手术前后脑局部皮层血流变化的研究  

Change of regional cerebral blood flow after resection of giant cerebral arteriovenous malformation

作　　者：格桑顿珠[1] 赵继宗[2] 王硕[2] 赵元立[2] 张东[2] 石广志[2] 

机构地区：[1]西藏自治区第二人民医院,拉萨850000 [2]北京天坛医院

出　　处：《山东医药》2010年第12期12-14,共3页Shandong Medical Journal

摘　　要：目的研究巨大脑动静脉畸形(AVM)手术切除后的脑皮质血流变化,指导临床降压治疗及血压监测等。方法AVM直径>6 cm的患者26例,用激光多普勒血流仪(LDF)分别记录切除AVM前、术后即刻、术后1 d、术后2 d、术后3 d的脑血流值,比较血流变化情况,观察术后脑血流稳定和再灌注水平下降所需时间。结果巨大脑AVM切除后脑局部的皮层血流较术前立即增高(P<0.05),术后2 d与术后1 d、术后即刻比较均无明显改变(P>0.05);术后3 d较术后2 d有所降低(P<0.05)。讨论巨大AVM切除后局部脑组织的血流明显增加,术后2 d达最高,术后3 d开始有明显的下降,但尚未达到术前的水平。Objective To investigate pre- and post-operative changes of regional cerebral cortical blood flow in patients with giant cerebral arterioneous malformation （AVM）. Methods Twenty-six adult patients with giant AVM were entered into this study. The diameter of AVM was more than 6 cm. Cortical blood flow （CBF） was measured by using laser Doppler flowmeter （LDF） at before, after AVM resection, 1, 2 and 3 days after operation. Results The CBF increased immediately after AVM resection and continued for 3 days after operation （ P 〈 0.05 ）. The CBF decreased obviously at the 3rd day after operation than that of previous day （P 〈 0.05）. Conclusion The CBF of giant AVM after AVM resection increased obviously especially at the 2nd day after operation. The CBF decreased at the 3rd post-operative day yet still higher than operation before.

关 键 词：颅内动静脉畸形 局部血流 神经外科手术 

分 类 号：R651.1[医药卫生—外科学]