黄芪多糖对PCV2阳性猪外周血免疫细胞及相关细胞因子的影响  

Effects of APS on peripheral blood immunocytes and related cytokines in PCV2 antigen-antibody positive pigs

作　　者：赵娟[1,2] 刘凤华[3] 邱河辉[1,2] 王安如[1,2] 朱晓宇[1,2] 程桂林[3] 王伟[3] 许剑琴[1] 

机构地区：[1]中国农业大学动物医学院中兽医实验室,北京海淀100193 [2]农业部兽用化药和中草药创制与评价重点开放实验室,北京海淀100193 [3]北京农学院动物科学技术系,北京昌平102206

出　　处：《中国兽医杂志》2010年第3期3-5,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金项目(30771591;30771566);"十一五"国家科技支撑计划(2007BAQ01041;2008BADB4B01;2008BADB4B07);北京市自然科学基金(6082007)

摘　　要：检测外周血T淋巴细胞、嗜中性粒细胞、CD4+、CD8+细胞百分数及IL-2、IL-4和IFN-γ含量的变化,研究黄芪多糖(APS)对PCV2阳性猪免疫功能的调节作用。结果显示,APS能显著增加外周血T淋巴细胞、NBT阳性细胞、CD4+T细胞百分数及IL-2、IL-4、IFN-γ含量,显著降低CD8+T细胞百分数,推测APS通过上调CD4+细胞百分数、CD4+/CD8+及Th1反应恢复正常免疫机能。The percentages of peripheral blood ANAE＋T lymphocytes,neutrophils,CD4^＋ and CD8^＋ cells,and the contents of IL-2,IL-4,IFN-γ were detected to study the immunomodulatory effects of APS on the immune functions of PCV2 antigen-antibody positive pigs.The results showed that APS can significantly increase the percentages and contents of these parameters besides decreased percentages of CD8^＋ T cells,suggesting that APS may upregulate the percentage of CD4^＋ cells,CD4^＋/CD8^＋ and Th1 reaction to improve the immune functions.

关 键 词：PCV2阳性猪 黄芪多糖 免疫细胞 IL-2 IL-4 IFN-γ 

分 类 号：S852.659.2[农业科学—基础兽医学]