创伤性脑损伤患者血浆β-内啡肽 强啡肽A1-13水平的研究  

Study of plasma β - endorphin and dynorphin levels in the patients with traumatic brain injury

作　　者：李锦忠[1] 农善华[1] 黄泽汉[1] 罗章伟[1] 张高炼[1] 农彩梅[1] 

机构地区：[1]右江民族医学院附属医院急诊科,广西百色533000

出　　处：《中国急救医学》2010年第3期227-229,共3页Chinese Journal of Critical Care Medicine

基　　金：广西百色市科技局攻关项目（No.2008-015）

摘　　要：目的探讨内源性阿片肽在创伤性脑损伤发病机制中的作用。方法采用放射免疫分析法（RIA）测定30例全麻颅脑手术患者和30例全麻非颅脑手术患者术前、术后及30例正常人血浆β-内啡肽（β-endorphin，β-EP）和强啡肽A1-13，（dynorphin，DynA1-13）含量。结果①60例手术患者术后血浆β-EP含量显著升高（P〈0．01），两组比较差异无统计学意义（P〉0．05）；②颅脑手术患者术后DynA1-13，含量显著升高（P〈0．01），与非颅脑手术患者比较差异有统计学意义（P〈0．01）；③不同部位颅脑手术患者血浆β-EP和DynA1-13，含量比较差异无统计学意义（P〉0．05）。结论内源性阿片肽在创伤性脑损伤病理生理过程中发挥的作用不同。B—EP在机体应激状态时普遍升高，血浆DynA1-13，含量是创伤性脑损伤的特异性指标，DynA1-13，含量与脑损伤部位无关。Objective To study the effects of endogenous opioid peptides on the pathogenesis of traumatic brain injury. Methods To determine plasma β - endorphin（ β - EP） and dynorphin A1-13 （ DynA1-13 ） levels in 30 cases of normal human, and 30 cases of general anesthesia craniotomy patients and 30 cases of general anesthesia non - brain surgery before brain surgery and after brain surgery by radioimmunoassay （RIA）. Results ①Plasma β -EP levels significantly increased in 60 cases after surgery（ P 〈 0. 01 ）, two surgery groups showed no significant difference （ P 〉 0. 05 ） ;②After brain surgery, patients＇plasma DynA1-13 were significantly higher （P 〈 0. 01 ）, the two surgery groups were significantly different（P 〈 0. 01 ） ;③In the patients with different parts of brain surgery, β -EP and DynAl_13 levels showed no significant difference （P 〉 0.05 ）. Conclusion In the process of pathophysiology of traumatic brain injury, the endogenous opioid peptides have different effects. In the body＇s stress state, β- endorphin generally increases, plasma level of DynA1-13 is a specific indicator of traumatic brain injury, DynA1-13 content has nothing to do with the brain injury site.

关 键 词：Β-内啡肽 强啡肽 创伤性脑损伤 

分 类 号：R722.12[医药卫生—儿科]