磷酸化蛋白激酶B在子宫颈癌组织中的表达及意义  

Expression of phosphorylated protein kinase B in carcinoma cervicis

作　　者：文政芳[1] 户瑞丽[1] 王世进[1] 华彩虹[1] 

机构地区：[1]新乡医学院第一附属医院妇产科,河南卫辉453100

出　　处：《新乡医学院学报》2010年第1期36-38,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨子宫颈癌组织中磷酸化蛋白激酶B(p-PKB)的表达及其在子宫颈癌发生、发展中的意义。方法采用免疫组织化学SP法检测51例子宫颈癌组织、36例子宫颈上皮内瘤变(CIN)组织和20例正常子宫颈组织中p-PKB蛋白的表达,并分析其与子宫颈癌临床病理因素的关系。结果p-PKB在子宫颈癌组织中的阳性表达率明显高于CIN组织和正常子宫颈组织(P<0.05)。p-PKB蛋白的表达与子宫颈癌组织学分级、临床分期及有无淋巴结转移有关(P<0.05)。结论p-PKB蛋白在子宫颈癌中过表达可能参与子宫颈癌的发生。Objective To investigate the expression of phosphorylated protein kinase B（p-PKB） in human cervical carcinoma and the effects in the tumorigenesis and progression of the human cervical carcinoma.Methods Expression of p-PKB protein was detected by using SP immunohistochemical staining in specimens of 51 cases of cancer of cervix,36 cases of cervix intraepithelial neoplasia,and 20 cases of normal cervical tissue.The relationship between p-PKB protein expression and the clinicopathological factors in carcinoma cervical was analyzed.Results The rate of positive expression of p-PKB in cervical carcinoma was remarkably higher than that in CIN and in normal cervical tissue,the differences were statistically significant（P0.05）.The expression of p-PKB was correlated to clinical stage,differentiation degree and lymph node metastasis（P0.05）. Conclusion The overexpression of p-PKB in carcinoma cervical may correlate with carcinogenesis and progression of carcinoma cervical.

关 键 词：磷酸化蛋白激酶B 子宫颈癌 免疫组织化学 

分 类 号：R711.74[医药卫生—妇产科学]