律复康胶囊对哇巴因致豚鼠心律失常模型作用的实验研究  

Study of Lvfukang capsules on experimental arrhythmia induced by ouabain in guinea pigs

作　　者：韩丽华[1] 王振涛[1] 陈舒茵[2] 申洪超[2] 黎瑞汝[2] 梁生旺[2] 

机构地区：[1]河南省中医院,河南郑州450003 [2]广东药学院中药学院,广东广州510006

出　　处：《中国医院药学杂志》2010年第6期452-454,共3页Chinese Journal of Hospital Pharmacy

基　　金：河南省科技创新人才计划项目(编号:0621002700)

摘　　要：目的:通过观察律复康胶囊对哇巴因致豚鼠心律失常模型的对抗作用,为临床用药提供依据。方法:取实验豚鼠50只,均分为模型对照组(等容量纯化水)、阳性对照组(4.185g.kg-1)、律复康胶囊小剂量(1.539g生药/kg)、中剂量(3.078g生药/kg)、大剂量(6.156g生药/kg)组,各组豚鼠按剂量连续给药3d,末次药后30min,用哇巴因致豚鼠心律失常模型,用Medlab生物信号采集处理系统记录豚鼠插肢体电极检测标准Ⅱ导心电图,分别记录出现室性早搏、心室颤动和心脏停搏时哇巴因用量。结果:律复康胶囊各剂量组豚鼠出现早搏、室颤和停博时所需哇巴因的剂量显著提高,与模型组比有显著性差异(P<0.01或P<0.05)。结论:律复康胶囊能够显著增加诱发豚鼠出现心律失常时哇巴因的剂量,说明律复康胶囊对哇巴因诱发的心律失常有一定对抗作用。OBJECHVE To observe the anti arrhythmic effects of Lvfukang capsules on the experimental arrhythmic models induced by ouabain in guinea pigs, and provid accordance for clinical medication. METHODS 50 guinea pigs were divided into control group, positive control group, high, middle and low dosage groups of Lvfukang capsules, respectively. All the dosage groups were given successively medication for 3 days, Arrhythmic models were induced by injection of ouabain for 30 rain after the last dosage of Lvfukang capsules in guinea pigs. Used the signal of Medlab biological processing system to record standard ]] electrocardiogram of guinea pigs interpolated with limb electrode of detection. And the threshold doses of ouabain of ventric ular premature beat （VP） ,ventricular fibrillation （VF） and asystole were recorded. RESULTS All the dosage groups of I.vfu- kang capsules significantly increased the threshold doses of ventricular premature beat （VP） , ventricular fibrillation （VF） and asystole of arrhythmic models of guinea pigs （P〈0. 05 or P〈0. 01）. CONCLUSION I.vfukang capsules has antiarrhythmic effects on the experimental arrhythmic models induced by ouabain.

关 键 词：律复康 心律失常 哇巴因 豚鼠 

分 类 号：R963[医药卫生—微生物与生化药学]