硝酸舍他康唑泡腾胶囊的制备工艺和含量测定  

Preparation and assaying of sertaconazole nitrate effervescent capsules

作　　者：金从形 黄微微 杜有功[4] 陈赛贞[4] 徐珊珊[4] 张英[4] 

机构地区：[1]浙江三门县中医院药剂科,三门317100 [2]温州医学院药学院 [3]浙江恩泽医药公司 [4]浙江台州医院药剂科,临海317000

出　　处：《中国临床药学杂志》2010年第2期111-114,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的研究硝酸舍他康唑泡腾胶囊的制备工艺及含量测定。方法确定处方的组成，制备泡腾胶囊，并用紫外分光光度法测定硝酸舍他康唑的含量。结果紫外分光光度法测定硝酸舍他康唑含量的标准曲线为A=0．0075p＋0．0096（r=0．9997），在质量浓度10～90mg·L^-1内吸光度与质量浓度之间的线性关系良好。结论该泡腾胶囊的制备方法简单，用紫外分光光度法测定含量，方法可靠。AIM To study the preparation and assaying method of sertaconazole nitrate effervescent capsules. METHODS The sertaconazole nitrate effervescent capsules were prepared and the assaying method with ultraviolet spectrophotometry was established after the formulation was eonfimed. RESULTS The standard curve of sertaconazole nitrate was A = 0.007 5p ＋ 0.009 6,with a good linearity（ r = 0.999 7） in the range of 10 - 90 mg·L^-1. CONCLUSION The preparation method is simple and the assaying method with ultraviolent spectrophotometry is reliable.

关 键 词：硝酸舍他康唑 泡腾胶囊 含量测定 紫外分光光度法 

分 类 号：R927.2[医药卫生—药学]