用复杂网络挖掘分析冠心病证候-治法-中药关系  

Analysis of relationships among syndrome,therapeutic treatment,and Chinese herbal medicine in patients with coronary artery disease based on complex networks

作　　者：高铸烨[1] 张京春[1] 徐浩[2] 史大卓[1] 付长庚[1] 曲丹[2] 周雪忠[3] 

机构地区：[1]中国中医科学院西苑医院心血管科,北京100091 [2]中日友好医院全国中西医结合心血管病中心,北京100029 [3]北京交通大学计算机与信息技术学院,北京100044

出　　处：《中西医结合学报》2010年第3期238-243,共6页Journal of Chinese Integrative Medicine

基　　金：国家科技支撑计划项目(No.2007BAI10B02);北京市科技计划重大项目(No.D08050703020801);国家重点基础研究发展计划(973计划)资助项目(No.2006CB504803)

摘　　要：目的:分析冠心病证候、治法和药物之间的关系。方法:采用病证结合的方法,调查3018例冠心病住院患者的临床信息;基于冠心病个体化诊疗信息平台,用复杂网络挖掘分析冠心病患者证候-治法-用药关系。结果:冠心病常见证候要素依次为血瘀、气虚、痰浊、阴虚、阳虚、气滞、血虚。与常见证候要素构成复杂关联的治法主要有活血、清热、补气、化浊(痰)、养阴、温阳、宣痹,与常见证候要素构成复杂关联的药物主要有黄芪、陈皮、地黄、川芎、白术、桃仁、茯苓、甘草、半夏、泽泻、赤芍、当归、丹参、枳壳、桂枝、麦冬,与常见证候要素构成关联的药物功效有止痛、化浊(痰)、清热、活血、补气、凉血、利水、化瘀、解毒、补血、理气、安神、补脾、调经、通便、润燥、散结。结论:冠心病中医临床诊疗符合理法方药相一致的原则,治疗冠心病的清热治法、解毒治法值得进一步研究。Objective： To analyze the relationships among syndrome, therapeutic method and Chinese herbal medicine in patients with coronary artery disease （CAD）. Methods： Using cross-sectional survey, we collected the clinical information of hospitalized CAD patients through individualized Information Acquisition Platform of CAD. The relationships among syndrome, therapeutic treatment and Chinese herbs were excavated by means of complex networks based on theory of correspondence between prescription and syndrome. Results： The fundamental syndrome factors were blood stasis, qi deficiency, phlegm-turbid, yin deficiency, yang deficiency, qi stagnation, and blood deficiency. The therapeutic treatment mainly included activating blood circulation, clearing heat, invigorating qi, resolving turbid and phlegm, nourishing yin, warming yang qi, and dispersing obstruction. These methods constituted an association with major syndrome factors. The major syndrome factors constituted an association with the following Chinese herbal medicines： Huangqi （Radix Astragali Mongolici ）, Chenpi （ Pericarpium Cirri Reticulatae ）, Dihuang （ Radix Rehmanniae ）, Chuanxiong （ Rhizoma Chuanxiong ） , Baizhu （ Rhizoma A tractylodis Macrocephalae ） , Taoren （ Semen Persicae ） , Fuling （ Poria ）, Gancao （ Radix Gfycyrrhizae ）, Banxia （ Rhizoma Pinelliae ）, Zexie （ Rhizoma Alismatis ）, Chishao （Radix Paeoniae Rubra ）, Danggui （ Radix Angelicae Sinensis ） , Danshen （Radix Salviae Miltiorrhizae ） , Zhiqiao （ Fructus Aurantii Subma turus . ）, Guizhi （Ramulus Cinnamomi ） and Maidong （ Radix Ophiopogonis Japonici）. The efficacy of Chinese berbal medicines constituting association With syndrome factors mainly included alleviating pain, resolving turbid and phlegm, clearing heat, activating blood circulation, invigorating qi, cooling blood, promoting urination, resolving stagnation, removing toxic material, nourishing blood, regulating qi, quieting spirit, invigorating spleen, regulating me

关 键 词：冠状动脉心脏病 治法 证候 药物和方剂 复杂网络 

分 类 号：R259[医药卫生—中西医结合]