生物材料中基体及涂层材料的理论研究与进展  

Theoretical research and progress of basal body and bio-coatings in biomaterial field

作　　者：王文静[1] 黄剑锋[1] 李颖华[1] 曹丽云[1] 

机构地区：[1]教育部轻化工助剂化学与技术重点实验室陕西科技大学,陕西省西安市710021

出　　处：《中国组织工程研究与临床康复》2010年第3期505-508,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：陕西省教育厅自然科学专项基金(08JK220);教育部新世纪优秀人才支持计划(ENCT-06-0893);陕西科技大学博士科研创新基金(BS09-09);陕西省自然科学基金(SJ08-ZT05);陕西科技大学研究生创新基金等基金赞助~~

摘　　要：背景:在生物材料特别是生物涂层领域的研究中,寻找一种既具有优良生物性能又具有良好力学性能的基体材料并以适当的方法制备出表面均匀致密、结合力较高的涂层是限制人工假体能否真正应用于临床的一个关键因素。目的:对生物涂层材料的研究进展做一综述。方法:应用计算机检索CNKI、中国标准全文数据库和Science Direct数据库中1998-01/2009-10关于生物材料的文章,在标题和摘要中以"生物涂层,羟基磷灰石,钛合金,碳/碳复合材料"或"Biocoatings;HAp;Titanium;Carbon/carbon composites"为检索词进行检索。选择文章内容与生物涂层材料有关者,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到216篇文献,根据纳入标准选择关于生物涂层材料的31篇文章进行综述。结果与结论:通过对钛合金与碳/碳复合材料两种基体材料以及各种涂层制备工艺的对比发现,碳/碳复合材料作为基体材料,不但具有很好的生物相容性,而且与天然骨的力学强度匹配,利用水热电泳沉积技术,结合羟基磷灰石、壳聚糖、有机玻璃等涂层材料的生物性能,制备以碳/碳为基体的复合涂层,有望为提高涂层与基体的结合强度提供新的思路和方法。BACKGROUND：In the research of biomaterial,especially bio-coatings field,how to find a good biological and mechanical properties basal body,and to prepare coatings with uniform and compact surface and strong bonding force,is the key factor in clinical Application of artificial prosthesis.OBJECTIVE：To review the progress of bio-coatings.METHODS：Databases of CNKI,VIP,and Science Direct were retrieved with key words of＂Biocoatings,HAp,Titanium,Carbon/carbon composites＂to search pApers published from January 1998 to October 2009.PApers underlying bio-coatings were selected.Totally 216 literatures were initial searched,according to inclusive criteria,31 literature were summarized.RESULTS AND CONCLUSION：By contrasting the basal bodies made of titanium or carbon/carbon and different coating preparation,we found that the basal body composed of carbon/carbon composites exhibited good biocompatibility,which had similar strength to natural bone.Using hydrothermal method,the composites coating prepared by taking carbon/carbon as basal body and hydroxyApatite,chitosan,or polymethyl methacrylate as coatings provided a new idea for increasing the combing strength between coatings and basal body.

关 键 词：生物涂层 羟基磷灰石 钛合金 碳/碳复合材料 水热电泳沉积 

分 类 号：R318[医药卫生—生物医学工程]