肝细胞微囊化技术理论进展与临床应用  

Physio-chemical progress and clinical application of microencapsulated hepatocytes

作　　者：王加祥[1] 韩宝三[1] 吴旭波[1] 余松林[1] 黄芳[1] 匡杰[1] 彭承宏[1] 

机构地区：[1]上海交通大学医学院瑞金医院,上海市200025

出　　处：《中国组织工程研究与临床康复》2010年第3期549-551,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家"十一五"高新技术研究发展计划-"863"项目(2008AA02Z417);上海市科委自然科学基金(07ZR14076);国家自然科学基金重点项目(20434030);国家自然科学基金(30672043;30772105;20074031;30801107);上海市教委科研创新项目(09YZ84)~~

摘　　要：肝细胞分离技术日趋成熟,肝细胞移植成为较热门的研究领域,但供体短缺和免疫排斥反应,制约了其广泛应用。肝细胞微囊化有助于为肝细胞移植的推广应用提供大量的具有高度活性和良好功能的肝细胞。文章就肝细胞微囊化技术及其应用进展进行综述,为肝细胞大规模、高活性体外培养及长期冻存提供了新的途径。With the development of cell separation technique,hepatocyte transplantation becomes a hot topic;however,the application is limited by donor deficiency and immunological rejection.Microencapsulated hepatocytes contribute to the promotion and application for liver cell transplantation,for which provide a large amount of high activity and good function of liver cells.In this paper,liver cell microencapsulation technology and its progress in applications were reviewed,providing prospective way for large-scale and high-active culture in vitro and long-term cryopreservation.

关 键 词：微囊 生物型人工肝 肝细胞移植 肝细胞 综述文献 

分 类 号：R318[医药卫生—生物医学工程]