急性期脑卒中患者和健康成人食指被动运动BOLD-fMRI  

Comparative Study of Cortical Activation between Patients with Acute Cerebral Infarction and Healthy Subjects During Passive Index Finger Movement Using BOLD-fMRI

作　　者：黄穗乔[1] 胡涛[1] 陈志光[2] 钟镜连[1] 肖芳[1] 袁小平[1] 

机构地区：[1]中山大学第二附属医院放射科,广州510000 [2]广东省中医院放射科,广州510000

出　　处：《放射学实践》2010年第3期271-275,共5页Radiologic Practice

基　　金：广东省自然科学基金资助项目(7301383)

摘　　要：目的:对比分析急性期脑梗死患者与健康成人各运动相关脑区激活程度和方法的差异,探讨急性期脑梗死后运动功能变化的模式。方法:对12例基底节区急性期缺血性脑梗死患者(实验组)和与之相匹配的12例健康成人(对照组)进行食指被动运动BOLD-fMRI检查,然后应用SPM对功能图像进行处理分析,并选取初级感觉运动区(SM1)、次级感觉运动区(SM2)、运动前区(PM)、补充运动区(SMA)、扣带回运动区(CMA)及小脑作为兴趣区,观察两组受试者各运动相关脑区的激活情况,并对对侧SM1区的激活体积、激活率进行定量分析。结果:对照组主要激活对侧SM1区(激活体积中位数1006k,四分位间距1142k,激活率100%),其它运动相关脑区激活次数较少,且激活体积相对较小;患者组主要激活对侧SM1区(激活体积中位数15k,四分位间距71k,激活率58.3%),其它运动相关脑区偶尔或无激活。患者组对侧SM1激活率、激活体积均比对照组低(P(0.05)。结论:BOLD-fMRI是一种研究脑梗死患者运动功能的有效方法。Objective：To investigate the pattern of cerebral cortex activation changes of various motor related areas in patients with acute cerebral infarct compared with that of normal subjects with BOLD function MRI （fMRI） study. Methods： 12 patients had acute cerebral ischemic infarction of basal ganglion area （experimental group） and 12 matched normal subjects （control group） underwent BOLD fMRI with passive index finger movement. The functional images were managed and analyzed by statistical parametric mapping （SPM）. The primary sensorimotor cortex （SM1）, secondary sensorimotor cortex （SM2） ,premotor cortex （PM） ,supplementary motor area （SMA） ,motor area in gyrus cingula （CMA） and cerebel- lum （CB） were chosen as the regions of interest. The activation of cortex related to movement in both experimental group and control group were evaluated and the activation volumes and frequencies of the contralateral SM1 were quantitatively analyzed. Results： For the control group, the activated area mainly located in the contralateral SM1 （the median of activation volumes was 1006k,the interquartile range was 1142k; the activation frequency was 100 %）, the frequency of other cortex areas activated related to movement were less and the volume was relatively smaller. The activated areas of experimental group were also mainly located in the contralateral SM1 （the median of activation volumes was 15k,the interquartile range was 71k;the activation frequency was 58.3 %）, the other areas of cortex showed minimum or almost no activation related to movement. The activation frequencies and volumes of the contralateral SM1 were lower/smaller in experimental group when compared with the control group （P〈0.05）. Conclusion：BOLD fMRI is a useful technique for the study of movement function in patients with cerebral infarction.

关 键 词：脑卒中 功能性磁共振成像 被动运动 

分 类 号：R445.2[医药卫生—影像医学与核医学]