抽动秽语综合征患者对指运动的功能磁共振成像  

Function MRI Study with Finger-taping Task in Tourette′s Syndrome Patients

作　　者：黎桂平[1] 杨波[2] 张金山[2] 马林[2] 蔡幼诠[2] 祝望才[1] 孙仁荣[1] 寥凯兵[1] 

机构地区：[1]湖北省新华医院放射科,武汉430015 [2]中国人民解放军总医院放射科,北京100853

出　　处：《放射学实践》2010年第3期280-284,共5页Radiologic Practice

摘　　要：目的:分析抽动秽语综合征(TS)患者和正常对照组对指运动脑激活区的差异,初步探讨TS患者运动异常的可能机制。方法:14例TS患者和14例年龄性别匹配的健康志愿者(对照组),采用fMRI技术对比分析在复杂对指过程中TS患者和健康志愿者的脑激活特点,并比较其激活范围。结果:两组受试者顺次对指运动共同激活的脑区包括双侧小脑半球(同侧比对侧激活明显)、双侧的中央前后回(对侧大于同侧)、双侧顶上小叶、对侧扣带回和对侧额内侧回。两组受试者激活不同的脑区:TS组可见双侧丘脑和豆状核的激活;TS患者同侧小脑半球激活范围比正常组大,两者差异有显著性意义;TS患者双侧中央前后回的激活范围比正常组大:左手对指运动时,TS组右侧中央前后回体积为(6192.35±30.50)mm3,左侧中央前后回体积为(896.67±29.16)mm3;对照组右侧中央前后回体积为(2712.47±13.03)mm3,对照组左侧中央前后回体积为(920.91±41.27)mm3,两者差异有显著性意义(右侧中央前后回体积:P<0.05;左侧中央前后回体积:P<0.05);右手对指头运动时,TS组左侧中央前后回体积为(7057.03±15.83)mm3,右侧中央前后回体积为(862.35±24.10)mm3;对照组左侧中央前后回体积为(3493.67±17.40)mm3,右侧中央前后回体积为(572.20±24.57)mm3,两者差异有显著性意义(右侧中央前后回体积:P<0.05;左侧中央前后回体积:P<0.05)。双侧顶上小叶体积两组资料差异有显著性意义,TS患者大于正常组。结论:TS的发生是基底节、丘脑异常为主的多个脑区参与的疾病,丘脑、纹状体、大脑皮层在TS的发病机制可能是关键的结构和功能区。Objective：To study the differences of activation patterns in the brain of patients with Tourette＇s syndrome （TS） and control subjects during performance of complex finger-taping task,and to investigate the potential mechanism of the abnormal motor function in the patients with TS.Methods：Participants were fourteen patients with Tourette syndrome （TS group） and fourteen gender and age matched healthy volunteers with no history of physical,psychiatric or neurological disease （control group）.Function MRI （fMRI） of the brain was performed during intermittent finger-taping task stimulation,and the characteristics of activation were evaluated.The areas and the volume of activation were compared between the two groups.Results：During the finger-tapping stimulation,the activated regions in the two groups were similar in bilateral cerebellum （ipsi-lateral more obvious than contralateral）;bilateral gyri pre-and post-centralis （contralateral larger than ipsi-lateral）;bilateral superior parietal gyrus,contralateral gyrus cinguli and contralateral medial frontal gyrus.There were different activation areas showed in the two groups：activation of bilateral thalamus and lenticular nuclei were showed in TS group;the volume of activated cerebellum in TS group was larger than that of control group,with significant difference （P〈0.05）.The activated areas in bilateral gyri pre-and post-centralis of TS group were larger than the control group.With the left finger taping movement,the volume of right gyri pre-and post-centralis were （6192.35±30.50）mm^3,of left gyri pre-and post-centralis were （896.67±29.16）mm^3 in TS group;and the volume of right gyri pre-and post-centralis were （2712.47±13.03）mm^3,of left gyri pre-and post-centralis were （920.91±41.37）mm^3 in control group,with significant statistical differences （right gyri pre-and post-centralis,P〈0.05;left gyri pre-and post-centralis,P〈0.05）.With the right finger taping movement,the volume of leftt gyri pre-and post-c

关 键 词：抽动秽语综合征 丘脑 纹状体 功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]