基于快速原型的组织工程支架成形技术  

Fabrication Technology of Tissue Engineering Scaffold Based on Rapid Prototyping

作　　者：颜永年[1,2] 李生杰[1,2] 熊卓[1,2] 王小红[1,2] 张婷[1,2] 张人佶[1,2] 

机构地区：[1]清华大学机械工程系,北京100084 [2]清华大学先进成形制造教育部重点实验室,北京100084

出　　处：《机械工程学报》2010年第5期93-98,共6页Journal of Mechanical Engineering

基　　金：国家自然科学基金(50575118);中国博士后科学基金(20070410055)资助项目

摘　　要：组织工程是生物制造的重要发展阶段,通过先成形生物材料的支架,然后在上面复合细胞的方式,来实现组织器官的人工制造。支架的性能在组织工程的应用中非常重要。相比传统的支架成形方法,基于离散—堆积原理的快速原型技术,所制造的支架个性化程度较高:支架的孔隙率、力学性能、生物相容性和降解特性等方面,可以通过参数设计和材料选择的方法进行人工设定;因此非常适于构建结构性的组织和器官。介绍了现有的基于快速原型的组织工程支架的成形技术,总结了其特点及应用现状,并分析讨论了其优缺点。Tissue engineering is an important development stage of bio-manufacturing. It constructs the tissue/organs by firstly fabricating the biomaterial scaffolds, and then planting the cells on them. The performance of the scaffold is very important to the application of tissue engineering. Compared to traditional scaffold manufacturing methods, rapid prototyping technology based on dispersed-accumulated principle manufactures scaffold that has high degree of personality： the porosity, the mechanical properties, the biocompatibility and biodegradation characteristic can be set through parameter design and material selection. Therefore it is very suitable for construction of structural tissue/organs. Here kinds of tissue engineering scaffold fabricating technologies based on rapid prototyping are introduced; their features and applications are summarized; their advantages and disadvantages are analyzed and discussed.

关 键 词：快速原型 组织工程 支架 生物制造 

分 类 号：TH164[机械工程—机械制造及自动化]