血管化脂肪组织研究进展  

Progress in Development of Vascularized Adpipose Tissues

作　　者：崔同魁[1,2] 颜永年[1,2] 张人佶[1,2] 徐铭恩[1,2] 王小红[1,2] 

机构地区：[1]清华大学机械工程系,北京100084 [2]清华大学先进成形制造教育部重点实验室,北京100084

出　　处：《机械工程学报》2010年第5期99-104,共6页Journal of Mechanical Engineering

基　　金：国家自然科学基金(30970748;30600140;30540060;30440043);国家自然科学基金与香港研究资助局联合(50731160625)资助项目

摘　　要：由于先天发育不良、肿瘤切除、外伤等原因引起的女性小乳症、乳房缺失等会给患者造成极大的心理障碍。血管化脂肪组织的研究针对大尺度范围内脂肪组织工程产品血液供应这一问题,研究脂肪组织中血管的排布规律,研究用于脂肪组织构建的基质材料、细胞种类、生长因子的用量及配比,利用计算机辅助设计等先进成形手段对血管化脂肪组织植入物进行三维结构模型设计,快速制造并进行生物学评价。为大尺度范围内脂肪组织损伤患者提供更加完善的修复手段,为复杂器官乳房的制造奠定基础。Due to congenital dysplasia, tumor resection, traumatic injuries and some other reasons, small breast and breast lost of females cause a great deal of mental handicap to the patients. The research of vascularized adipose tissues, aiming at solving the blood supply of large scale adipose tissue engineering products, includes the investigation of the arrangement of blood vessels in adipose tissues, the matrix materials, cell types and growth factors for volume stable adipose tissue reconstruction and the three-dimensional structural model design by using advanced fabrication methods such as computer-aided design, rapid prototyping manufacture and biological evaluation. It is hoped that the vascularized adipose tissues can provide more valuable repair results for patients and establish foundation for the manufacturing of complex organ of breasts.

关 键 词：血管化 脂肪组织 干细胞 细胞组装 快速成形 

分 类 号：R318.1[医药卫生—生物医学工程]