160例重复体外受精-胚胎移植周期临床结局分析  

Analysis of the clinical outcomes of 160 patients undergoing repeated IVF/ICSI-ET treatment

作　　者：李秋华[1] 全松[1] 陈雷宁[1] 李红[1] 高瑞花[1] 倪郝[1] 余敏[1] 陈思梅[1] 罗琛[1] 

机构地区：[1]南方医科大学南方医院妇产科生殖医学中心,广东广州510515

出　　处：《南方医科大学学报》2010年第2期236-238,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(30872769);南方医院新技术新项目基金(20060002)

摘　　要：目的探讨重复周期妊娠成功的影响因素。方法回顾分析我院生殖中心2006年1月～2009年4月89例行第2个体外受精-胚胎移植(IVF/ICSI-ET)周期妊娠患者(A组)和71例行第2个周期均未妊娠的患者(B组),分析2组患者基本情况、临床方案、卵母细胞和胚胎质量等因素对妊娠结局的影响。结果A组与B组相比,A组女方年龄较小、不孕年限短、基础卵泡数较多,且前者Gn总量少,但A组优质胚胎率、可移植胚胎数均高于B组(P<0.05)。A组第2个周期比第1个周期应用较多的GnRHa短效制剂、基因重组HCG、加用HMG、有较高的HCG日血中E2浓度,且优质胚胎率、可移植胚胎数、移植胚胎数等第2周期均比第1周期高(多)(P<0.05)。结论女性年龄是影响辅助生殖技术成功的重要因素之一;在重复IVF-ET周期中通过采用黄体期长方案及调节Gn的用量、调整GnRHa的制剂、适量加用HMG、应用口服避孕药预处理、更换培养基等措施可能有助于提高临床妊娠率。Objective To study the clinical factors affecting the outcomes of repeated assisted reproductive technology（ART） cycles.Methods A retrospective analysis of the clinical data and outcomes was conducted among 160 patients undergoing repeated IVF/ICSI-ET treatment between January 2006 and April 2009.Results The patients with successful clinical pregnancy after two ART cycles（group A） had a younger age and shorter duration of infertility,and had more antral follicles（AFC）,more eggs and good-quality embryos with more transferred embryos available and higher good-quality embryo rate（P〈0.05） than those who failed to have pregnancy after the cycles（group B）.In the second cycle,the patients in group A had higher doses of short-acting GnRHa,r-HCG and HMG and at the same time more good eggs and embryos than in the first cycle.Conclusion Female age is one of the most important factors affecting the pregnancy rate after repeated ART cycles.The clinical pregnancy rate can be enhanced by administering short-acting GnRHa,HMG,oral contraceptives and adjusting the dose of Gn as well as changing the culture medium of embryos.

关 键 词：重复辅助生殖周期 体外受精-胚胎移植 妊娠率 年龄 

分 类 号：R714.8[医药卫生—妇产科学]