胎膜早破时粒细胞集落刺激因子测定的临床意义  

DETECTION OF GRANULOCYTE COLONY STIMULATING FACTOR AND ITS SIGNIFICANCE IN PREMATURE RUPTURE OF FETAL MEMBRANES

作　　者：刘玉洁[1] 郑新芝 

机构地区：[1]北京医科大学第一医院妇产科

出　　处：《北京医科大学学报》1998年第6期550-551,564,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：了解胎膜早破时测定粒细胞集落刺激因子（ｇｒａｎｕｌｏｃｙｔｅｃｏｌｏｎｙｓｔｉｍｕｌａｔｉｎｇｆａｃｔｏｒ，ＧＣＳＦ）的临床意义。方法：测定６４例胎膜早破产妇在分娩时母血清及脐血清的ＧＣＳＦ和Ｃ反应蛋白（ｃｒｅａｃｔｉｎｇｐｒｏｔｅｉｎ，ＣＲＰ）水平，同时以６４例正常产妇做对照。结果：观察组母及脐血清ＧＣＳＦ阳性分别为１０和１２例，较对照组４和５例增高，Ｐ＜０．０５；血清ＧＣＳＦ和ＣＲＰ都异常或脐血清任何一项测定异常时，７５％～１００％新生儿发病；观察组与对照组分别有２６与１６例新生儿发病，Ｐ＜０．０５。Objective: To investigate the clinical significance of granulocyte colony stimulating factor (G CSF) in premature rupture of fetal membranes. Methods: 64 cases of pregnancy with premature rupture (study group) and 64 cases of normal pregnancy (control group) were detected for the G CSF and C reactie protein (CRP) levels in their maternal blood serum and cord blood serum. Results: In study group, 10 cases were found G CSF positive in maternal blood serum and 12 cases were found G CSF positive in cord blood serum, while in control group, 4 cases were found G CSF positive in maternal and 5 cases in cord blood serum. The positive cases in study group were more than that in control group. When maternal blood serum was found abnormal for both G CSF and CRP, or the cord blood serum was found abnormal, the neonatal morbidity was 75% to 100%. 26 cases in study group and 16 cases in control group were found to have neonatal diseases. Conclusion: Detection of G CSF level in serum was helpful to pre diagnose neonatal morbidity in premature rupture of fetal membranes.

关 键 词：胎膜早破 G-CSF 测定 C反应蛋白质 

分 类 号：R714.433[医药卫生—妇产科学]