氧流量对异氟烷的消耗与摄取的影响  

THE EFFECT OF OXYGEN FLOW ON THE UPTAKE AND CONSUMPTION OF ISOFLURANE

作　　者：戴 杨拔贤[1,2] 许幸 杨天明[1,2] 

机构地区：[1]北京医科大学第一医院麻醉科 [2]中国人民解放军303医院麻醉科

出　　处：《北京医科大学学报》1998年第6期562-564,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：探讨不同氧流量对异氟烷的消耗量和体内摄取的影响。方法：２４例异氟烷全身麻醉的病人，按新鲜氧流量不同随机分为３组。氧流量分别为２．０、１．０和０．３Ｌ·ｍｉｎ－１。以微量泵向呼吸环路吸入远端输入异氟烷，调节输入速度使肺泡异氟烷浓度维持在最低肺泡有效浓度的１１倍。监测异氟烷吸入及呼出体积分数，以吸呼体积分数差作为摄取指标，观察异氟烷的消耗量及体内摄取量的变化。结果：异氟烷的消耗量随氧流量的增大而明显增加；体内摄取量各组间差异无显著性。结论：在维持相同最低肺泡有效浓度时，异氟烷的消耗量随着新鲜氧流量的增加而增加；Objective:To investigate the effect of oxygen flow rate on the uptake and consumption of isoflurane. Methods: Twenty four patients anesthetized with inhalation of isoflurane were randomly divided into three groups receiving 2.0, 1.0 and 0. 3 L·min -1 oxygen flow, respectively. A micropump was connected to the distal limb of respiratory circuit on an Ohmeda anesthesia machine, injecting liquid isoflurane at a proper rate to keep minimum alveolar concentration (MAC) at the level of 1.10. The uptake and consumption of isoflurane among the three groups were compared. Results: The consumption of isoflurane was significantly increased as the oxygen flow rate increased. No significant differences were found in the uptake of isoflurane among the three groups. Conclusion: In maintaining a constant MAC, the consumption of isoflurane increases with the increases in oxygen flow; and the uptake is not related to the changes in oxygen flow.

关 键 词：异氟烷 代谢 药代动力学 氧流量 全身麻醉 

分 类 号：R614.21[医药卫生—麻醉学]