抗炎消瘿方干预EAT小鼠甲状腺激素及TGA、TMA水平的实验研究  

Empirical Study of Kangyan Xiaoying Recipe Interfere in Thyroid Hormones and TGA、TMA Level on EAT Mice

作　　者：秦晓康[1] 朱萱萱[2] 达庆国[2] 吴旭彤[2] 张忠华[2] 

机构地区：[1]南京中医药大学 [2]南京中医药大学附属医院,南京210029

出　　处：《中国医药导刊》2010年第3期457-458,460,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:通过研究应用抗炎消瘿方治疗自身免疫性甲状腺炎(EAT),来观察其对EAT小鼠甲状腺激素及抗体水平的影响。方法:联合应用甲状腺球蛋白(TG)与弗氏完全佐剂复制EAT小鼠模型后,随机分为正常组、模型组、甲状腺素组、强的松组、雷公藤组、抗炎消瘿方大剂量、中剂量、小剂量组实验,采用放射免疫法检测EAT小鼠血清中甲状腺激素T3、T4、FT3、FT4及血清甲状腺抗体TGA、TMA水平。结果:模型组T3、T4、FT3、FT4、TGA、TMA都高于正常组,差异有统计学意义(P<0.01)。抗炎消瘿方大剂量组T3、T4、FT3、FT4、TGA、TMA都低于模型组,差异有统计学意义(P<0.01,P<0.05)。结论:抗炎消瘿方对自身免疫性甲状腺炎具有治疗效果,能剂量依赖性地抑制体液免疫。Objective：Studied the application of Kangyan Xiaoying Recipe treatment of autoimmune thyroiditis （EAT）.to observe the role of thyroid hormone and antibody levels on EAT mice.Methods：Combined thyroglobulin （TG） with Freund＇s complete adjuvant replicated EAT mice modeLRandom divided into normal group.model group,thyroxine group,prednisone group,triptolide group,Kangyan Xiaoying Recipe high-dose.medium dose,low-dose group of experiments.Used radioimmunoassay to detect EAT fllyroid hormone in serum T3,T4,FT3,FT4,and serum thyroid antibodies TGA,TMA leveI.Results：T3,T4.FT3,FT4.TGA.TMA of model group is higher than the normal group,there were significant differences（P〈O.Ol ）.T3,T4,FT3,FT4,TGA,TMA of Kangyan Xiaoying Recipe high-dose group lower than model group.there were significant differences（P〈（）.01）.Conclusion：Kartgyan Xiaoying Recipe had a therapeutic effect on autoimmune thyroiditis.inhibited dose- dependen of humoral immunity.

关 键 词：自身免疫性甲状腺炎 抗炎消瘘方 甲状腺激素及抗体 

分 类 号：R285.5[医药卫生—中药学]