创伤性脑水肿甘露醇脱水治疗电阻抗断层成像实时监测的研究  

Study on application of electrical impedance tomography real-time surveillance for traumatic brain edema with mannitol dehydration

作　　者：费舟[1] 李兵[1] 付峰[2] 董秀珍[2] 林伟[1] 李侠[1] 胡世颉[1] 史学涛[2] 刘蒙[2] 

机构地区：[1]第四军医大学西京医院神经外科,710032 [2]第四军医大学生物医学工程系

出　　处：《临床神经外科杂志》2010年第1期3-6,共4页Journal of Clinical Neurosurgery

基　　金：863课题(2009AA02Z419);全军医药卫生科研基金科技攻关课题(08G106)

摘　　要：目的探讨甘露醇对脑组织脱水过程中脑部电阻抗的变化规律,研究电阻抗断层成像监护技术对甘露醇脱水功效的监护作用。方法使用电阻抗断层成像技术,实时监测12例保守治疗的颅脑损伤伤员甘露醇脱水过程中相应的电阻抗一维指标与二维图像变化,每人选取干扰较少的4次脱水过程进行分析,并记录相应的排尿量和液体摄入量,分析在甘露醇的脱水过程中电阻抗指标变化。结果 48次甘露醇脱水过程中,颅内液体量变化时相应组织的电阻抗一维指标也发生变化,当液体量减少时阻抗值升高,液体量回升时阻抗值降低,对应的EIT二维图像也发生相应的变化。结论连续实时EIT动态图像监护即可动态监护脑水含量改变,判别甘露醇的效果和指导拟定治疗方案,也有可能成为一种颅内病变脑含水量改变监测的有效方法。Objective To investigate the changing （EIT） effect. patterns of encephalic electric impedance during dehydration therapy with mannitol and to evaluate its significance in monitoring the Method EIT was applied to continuously monitor the process of dehydration therapy of twelve patients with head injury. The data of one dimensional index of electrical impedance and two dimensional image were recorded. For each subject, the index of electrical impedance in the preeess of dehydration was detected and analyzed for four times. And the urinary output and liqiud intake were recorded. Result In the process of dehydration, with the change of brain water content, two dimensional image changed accordingly. And the trend in changes of one dimensional index was inversely corelated with the change of brain water content. Conclusion EIT may be a potential tool for continuously monitor the change of brain water content. And it can be used to guide the mannitol prescription.

关 键 词：颅内压 EIT 甘露醇 

分 类 号：R318.04[医药卫生—生物医学工程]