中医药治疗感染后肠易激综合征思路探讨  

Discussion on Chinese medicine in treating post-infectious irritable bowel syndrome

作　　者：杨俭勤[1] 唐旭东[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中华中医药杂志》2010年第4期560-564,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技部国际合作项目(No.2007DFA30560)~~

摘　　要：感染后肠易激综合征的发病机制涉及肠道免疫屏障的异常,其可能涉及的病理环节包括:肠道和全身T淋巴细胞的变化;炎症性细胞因子的变化;肠道内肥大细胞的增多;肠嗜铬细胞的增多等。目前西医治疗大多以对症治疗为主,缺乏明显有效治疗手段。中医研究大多认为肠易激综合征(IBS)其本多在肝,因情志等因素导致肝之疏泄失常,肝脾气机失调酿成IBS证候群。肝郁脾虚,肝脾不和是本病的关键病机,在此基础上,在疾病的不同阶段,仍可能存在不同的病机。感染后肠易激综合征作为肠易激综合征一特殊类型,发病中正邪双方力量的对比决定其疾病进程,而在治疗上亦应当扶正不忘祛邪,补虚兼以去湿。The pathogenesis of post- infectious irritable bowel syndrome （ PI-IBS ） involves abnormal intestinal immune barrier, which possibly includes the pathological aspects： Intestinal and systemic changes in T lymphocyte; the change of inflammatory cytokines; a increase in intestinal mast cells and enterochromaffin cells and so on. Treatment by western medicine based largely on symptomatic treatment. TCM thinks that the fundamental organ of the irritable bowel syndrome is the liver. Emotional factors inducing liver dysfunction lead to the symptoms of irritable bowel syndrome. The pathogenesis of IBS is, the disorder of movement of qi in liver and spleen. Stagnation of liver-QI with deficiency of the spleen or disharmony between liver and spleen is the key pathogenesis of post-infectious irritable bowel syndrome. On this basis, in various stages of the disease, there may be a different pathogenesis. As a special type of IBS, the balance of vital qi and evil factors determine the disease progression of PI-IBS, in the treatment course also should not forget dispelling pathogenic factors while strengthening body resistance, tonifying deficiency and removing dampness o

关 键 词：感染后肠易激综合征 肠道免疫屏障 中医药治疗 

分 类 号：R259[医药卫生—中西医结合]