新疆维吾尔族女性HPV感染状况及其分布特征研究  

A cross-sectional study:The prevalence and distribution characteristic of HPV infection in Uygur women in Xinjiang

作　　者：李丽[1,2] 玛依努尔.尼亚孜 陈凤[3] 朱开春[1,2] 刘新伟 热孜亚.买买提孜 孙振柱[1,2] 赵丽霞[1,2] 张询[3] 潘秦镜[3] 刘新伏[3] 武燕萍[3] 乔友林[3] 

机构地区：[1]新疆医科大学 [2]新疆维吾尔自治区人民医院,乌鲁木齐830011 [3]中国医学科学院 北京协和医学院 肿瘤研究所,北京100021 [4]新疆和田地区于田县妇幼保健站,和田848000 [5]新疆和田地区于田县人民医院,和田848000

出　　处：《癌症进展》2010年第2期114-119,共6页Oncology Progress

基　　金：美国克利夫兰医学基金资助(项目编号:CMSI~#09301)

摘　　要：目的了解新疆维吾尔族女性HPV感染及其分布特征,为今后宫颈癌防治提供策略。方法采用横断面研究,于2006年在新疆于田县以整群抽样的方法选择年龄16～59岁、有性生活的维吾尔族女性约1000人行宫颈癌危险因素问卷调查和宫颈脱落细胞HPV DNA检测。所有女性均按年龄分层入组,先由调查员进行一对一的问卷调查,后由医师进行宫颈脱落细胞采样。将收集到的样本采用第2代杂交捕获(hc 2)试验进行HPV DNA检测。样本中检出的HPV DNA≥1.0 pg/mL即为感染阳性。结果共纳入883名新疆维吾尔族女性,平均年龄为36.26±10.10岁。其高危型HPV和低危型HPV感染率分别为7.25%和1.59%,总体HPV感染率为8.27%,明显低于中国汉族女性(16.1%)。HPV感染率在有2个以上性伴侣的女性中明显较高(x^2=5.254,P=0.022),但是在以下人群中无统计学差异:不同的年龄、教育和收入水平、初次性生活年龄及丈夫婚前、婚后有或无其他性伴侣。结论新疆维吾尔族女性HPV感染率明显低于中国汉族女性。其HPV感染可能与种族有一定关系,并受到性行为因素的影响。Objective To investigate the prevalence and distribution of HPV infection in Uygur women in Xinjiang Uygur Autonomous Region of China, so as to provide the prevention and treatment strategy for cervical cancer in the future. Methods A cross - sectional study was designed in 2006 in Yutian County. About 1, 000 16 - 59 - year - old Uygur women with sexual experience were selected by cluster sampling method. All people were stratified into groups according age for answering questionnaire and accepting HPV test （HC2）. All samples were tested for HPV DNA test using the second generation hybrid capture （Hybrid Capture 2） test. The quantities of HPV DNA detected in Specimens ≥ 1.0 pg / ml would be regarded as HPV positive. Results A total of 883 Uygur women were included in this study （ aged 36. 26±10. 10 years）. The prevalences of high - risk HPV and low - risk type HPV were 7. 25% and 1.59% respectively, and the prevalence of total HPV was 8.27% in Xinjiang Uygur women, which was significantly lower than that in Han Chinese women （16. 1% ）. HPV prevalences were not significantly different in the following strata： age, levels of education and income, age of the first intercourse, and husband have other sexual partners before or after marriage. Conclusions The prevalence of HPV in Xinjiang Uygur women is lower than that Han Chinese women, which may due to the differences in ethnic groups or sexual behavior- related factors, and affected by sexual factors.

关 键 词：维吾尔族 HPV感染 分布 

分 类 号：R711.74[医药卫生—妇产科学]