黄瓜香等中药调整腹水瘤小鼠肠道菌群减轻化疗副作用的研究  

Study of HUANGGUAXIANG modulate flora inbalance and alleviate chemo-treatment side effect

作　　者：任继秋[1,2] 吴庆田[1] 王跃生[3] 张涛[1] 马淑霞[1] 刘振平[3] 

机构地区：[1]佳木斯大学基础医学院微生物教研室,黑龙江佳木斯154007 [2]佳木斯大学儿童神经康复实验室,黑龙江佳木斯154007 [3]佳木斯大学第一附属医院普外科,黑龙江佳木斯154007

出　　处：《中国微生态学杂志》2010年第3期214-216,共3页Chinese Journal of Microecology

基　　金：黑龙江省中医管理局科研课题项目资助(ZHY08-Z86);黑龙江省自然基金项目(D2007-77)

摘　　要：目的通过黄瓜香等中药调整肝癌腹水瘤小鼠肠道菌群以减轻化疗的副作用达到预防和治疗肿瘤的目的。方法以小鼠腹腔内注射肝癌H22腹水瘤细胞造成肝癌腹水瘤模型,分别于造模型前1周用黄瓜香等和造模型后5 d用顺铂加上黄瓜香等进行治疗,并于注射后做HE染色检测肿瘤种植情况、血中白细胞、血小板的数量及巨噬细胞吞噬能力等。结果中药预防组与对照组相比肿瘤种植明显降低,中药加化疗组与阴性对照组比血中红细胞、白细胞和血小板均有回升(P<0.01),巨噬细胞吞噬率增加明显。结论黄瓜香等能调节机体免疫力,防治腹水瘤和减轻化疗的副作用。Objective To research function of HUANGGUAXIANG in modulating flora inbalanee of intestinal and improment quality of live and raise rate of live of hydroperitonia mice. Method The mice were injected aseites tumor H22 cell in intraperitoneal, then the mice were administrated with HUANGGUAXIANG orally. The vaty of intestinal flora, quatity of ascites and time of mice live were observe. Result Intestinal flora inbalance more and more, eascites producing was late, quatity of easeites reduced. The survival time of mice prolonged in groups of cure. Conclusion HUANGGUAXIANG not only can regulate intestinal microecology balance, but also prevent the formation of hepatocarcinoma hydroperitonia.

关 键 词：黄瓜香 腹水瘤 化疗 

分 类 号：S831.5[农业科学—畜牧学]