乙型肝炎肝硬化患者血脂变化的临床意义  

The clinical significance of the change of blood-lipid in patients with hepatitis B-related cirrhosis

作　　者：芦亚君[1,2] 张爱军[3] (辶居)红珍[1,2] 盛吉芳 

机构地区：[1]浙江大学医学院附属第一医院传染科 [2]传染病诊治国家重点实验室,浙江杭州310003 [3]慈溪市人民医院,浙江宁波315300

出　　处：《中国微生态学杂志》2010年第3期264-266,共3页Chinese Journal of Microecology

摘　　要：目的探讨乙型肝炎肝硬化患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及极低密度脂蛋白(VLDL-C)的临床意义。方法回顾性分析浙江大学医学院附属第一医院120例乙型肝炎肝硬化患者临床资料,同时选用我院30例健康体检者临床资料为正常对照。结果与正常体检者相比,乙型肝硬化患者血脂水平明显降低(P<0.05),TC、TG、HDL-C、LDL-C水平与白蛋白、胆碱酯酶水平正相关(P<0.01),TC、TG、LDL-C水平与凝血酶原时间、MELD分级负相关(P<0.01)。结论乙型肝硬化患者血脂水平明显降低,血脂水平与乙肝肝硬化患者肝功能损害明显相关。Objective To investigate the relation between the clinical significance and the levels of serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein（HDL-C）,low density lipoprotein（LDL-C） and very low density lipoprotein（VLDL-C）.Method A retrospective analysis of 120 cases of clinical data of patients with liver cirrhosis was performed,and the clinical data of 30 normal healthy individuals in our outpatient clinic were involved as a control group.Result Compared with normal healthy persons,lipid levels in patients with hepatitis B cirrhosis were significantly lower（P〈0.05）.Levels of TC,TG,HDL-C and LDL-C were positive correlated with levels of albumin and cholinesterase（P 0.01）.Levels of TC,TG and LDL-C were negative correlated with the levels of prothrombin time and MELD（Model for end-stage liver disease） classification（P〈0.01）.Conclusion The levels of blood lipid in patients with hepatitis B-related cirrhosis are significantly lower compared with normal persons.And levels of some blood lipids are significantly correlated with liver damage in patients with hepatitis B liver cirrhosis.

关 键 词：乙型肝炎 肝硬化 血脂 

分 类 号：R446.5[医药卫生—诊断学]