阻塞性睡眠呼吸暂停低通气综合征患者血脂变化的研究  

Study about the change of lipid metabolism in patients of obstructive sleep apnea-hypopnea syndrome

作　　者：李渝[1,2] 丁少芳[1,3] 陈晨[1,2] 王丽[1,3] 

机构地区：[1]首都医科大学附属北京安贞医院 [2]北京市心肺血管疾病研究所全科,北京100029 [3]北京市心肺血管疾病研究所呼吸科,北京100029

出　　处：《心肺血管病杂志》2010年第2期95-97,115,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨阻塞性睡眠呼吸暂停低通气综合征(Obstructive sleep apnea-hypopnea syndrome,OSAHS)患者的脂质代谢变化及临床意义。方法:选取100例打鼾患者为观察对象,均行多导睡眠图(PSG)监测,按PSG结果将其分为鼾症组16例、轻度OSAHS组21例、中度OSAHS组27例、重度OS-AHS组36例。所有患者于清晨睡眠醒后采外周血,测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋(HDL-C)、低密度脂蛋白(LDL-C)。分析各组血脂水平的变化,将患者血脂水平分别与睡眠呼吸监测指标进行直线相关性分析。结果:OSAHS组与健康对照组体质量指数(BMI)、TC比较差异有统计学意义(P<0.01);组间比较重度OSAHS组BMI明显高于轻、中度OSAHS组;中度、重度组与健康对照组的TC比较差异有统计学意义(P<0.05)。相关分析显示血清胆固醇(CHO)、LDL-C与睡眠呼吸暂停低通气指数(AHI)呈显著正相关(r=0.275,r=0.209,P<0.01),与最低脉博容积血氧饱和度(LSpO2)呈负相关(r=-0.211,P<0.05;r=-0.203,P<0.05)。结论:OSAHS可能导致血浆脂质代谢紊乱,慢性间歇性低氧血症及血浆脂质代谢紊乱,有促进动脉硬化的危险。Objective：To study the change of lipid metabolism in patients of obstructive sleep apnea/Hypopnea（OSAHS） and its significance in clinical practice.Methods：One hundred patients with snoring symptoms were chosen to be the study objects.They were separated into following groups according to polysomnogram（PSG） monitor results：simple snore group（n = 16）,mild OSAHS（n = 21）,moderate OSAHS（n = 27） and severe OSAHS（n = 36）.Peripheral blood was collected from every patient in the morning after fasting.The following indexes were measured in all groups：plasma triglycerides（TG）,plasma cholesterol（CHO）,plasma HDL（HDL-C）,plasma LDL（LDL-C）.Linear correlation analysis was performed to compare the lipid profiles and the indexes acquired from polysomnogram（PSG） monitoring.Results：One way ANOVA showed statistically significant difference among AHI,LSpO2,BMI,TG and LDL-C.There are significant positive correlations indicated between plasma CHO,LDL-C and AHI（r = 0.275,r = 0.209,P 0.01,respectively）.Negative correlations were found between plasma CHO,LDL-C and LSpO2（r =-0.211,r = 0.203,P 0.05,respectively）.Conclusion：Our current research indicated that,OSAHS can induce plasma lipid metabolism disorder.Chronic intermittent hypoxemia and dyslipidemia are risk factors for arteriosclerosis.

关 键 词：睡眠呼吸暂停综合征 阻塞性 体质量指数 血脂 

分 类 号：R56[医药卫生—呼吸系统]