肝囊型包虫病患者血清白细胞介素(IL)-17的检测及其临床意义  

Detection for Serum IL-17 Level in Patients with Cystic Echinococcosis and Its Clinical Significance

作　　者：吐尔洪江.吐逊 单娇宇[1] 刘弓伯[1] 克依木.居来提 耿诚[2] 帕提古丽[2] 林仁勇[1] 温浩[1] 

机构地区：[1]新疆医科大学第一附属医院医学研究中心新疆包虫病基础医学重点实验室,乌鲁木齐830054 [2]新疆医科大学第一附属医院消化血管外科中心,乌鲁木齐830054

出　　处：《地方病通报》2010年第1期5-6,11,共3页Endemic Diseases Bulletin

基　　金：国家自然科学基金(30960342);新疆维吾尔自治区包虫病基础医学重点实验室开放课题(XJDX0202-2008-07)

摘　　要：目的探讨血清Th17细胞相关因子IL-17在肝囊型包虫病患者中的表达及其临床意义。方法将56例受试者分为3组,健康志愿者(healthy donor,HD)组20例、肝囊型包虫病(cystic echinococcosis,CE)组21例和肝囊型包虫病复发(recurrent cystic echinococcosis,RCE)组15例;应用酶联免疫吸附法(ELISA)检测各组受试者Th17细胞相关细胞因子IL-17的表达。对数据进行t检验。结果血清IL-17水平在CE组(13.4±3.5)ρg/mL和RCE组(13.2±4.7)ρg/mL比对照组HD组(16.4±4.8)ρg/mL降低(t=2.27,t=2.20,P<0.05);RCE组与CE组之间差异无统计学意义(t=0.143,P>0.05)。结论血清IL-17在肝囊型包虫病患者中显著降低,可能与细粒棘球蚴感染过程中免疫调节有关。Objective To investigate the expression of Th17 related cytokine IL-17 in patients with cystic echinococcosis and its significance in immune modulation.Methods Fifty-six subjects were enrolled and divided into 3 groups,healthy donor（HD,n=20）,liver cystic echinococcosis（CE,n=21）,recurrent cystic echinococcosis（RCE,n=15）.The serum concentrations of IL-17 were measured by enzyme-linked immunosorbent assay.Results Serum IL-17 reduced in CE（13.4±3.5） ρg/mL and RCE（13.2±4.7） ρg/mL compared with HD group（16.4±4.8） ρg/mL（t=2.27,t=2.20,P0.05）.However there was no statistical significance between CE and RCE（t=0.143,P0.05）.Conclusions Decreased IL-17in patients with cystic echinococcosis may have correlation with immune modulation during infection progress of echinococcosis.

关 键 词：棘球蚴病 肝 白细胞介素-17 寄生虫感染 

分 类 号：R532.32[医药卫生—内科学] R446.6[医药卫生—临床医学]