黄芩苷与盐酸小檗碱在大鼠小肠吸收的相互作用研究  

Interaction of Baicalin with Berberine for Intestinal Absorption in Rats

作　　者：杜青青[1] 王战国[1] 刘芳[1] 蒋学华[1] 

机构地区：[1]四川大学华西药学院,成都市610041

出　　处：《中国药房》2010年第11期965-967,共3页China Pharmacy

基　　金：教育部博士点基金项目(20070610047)

摘　　要：目的:研究黄芩苷与盐酸小檗碱在大鼠小肠吸收的相互作用。方法:采用大鼠原位灌注模型研究药物配伍前、后大鼠小肠吸收动力学特征。结果:黄芩苷在配伍盐酸小檗碱前、后,其吸收速率常数(ka)与吸收率(A)分别为(0.068±0.002)h-1、(5.92±1.39)%和(0.060±0.002)h-1、(4.27±1.23)%;盐酸小檗碱在配伍黄芩苷前、后,其ka和A分别为(0.044±0.003)h-1、(3.47±0.64)%和(0.057±0.006)h-1、(5.18±0.83)%。药物配伍前、后,黄芩苷的ka有显著性差异(P<0.05),盐酸小檗碱的ka和A均有显著性差异(P<0.05)。结论:盐酸小檗碱可以抑制黄芩苷的吸收,黄芩苷可以促进盐酸小檗碱的吸收。OBJECTIVE：To study the interaction of baicalin with berberine for intestinal absorption in rats. METHODS： The mode was induced by in situ intestinal perfusion to observe the absorptive kinetics characteristic in rats＇ intestine before and after mixing. RESULTS： The absorption rate constant （ko） and absorption rate （A） of baicalin alone were （0.068 ± 0.002）h^-1 and （5.92 ± 1.39）% while those of baicalin mixed with berberine were （0.060 ± 0.002）h^-1 and （4.27 ± 1.23）% , respectively. ka and A of berberine alone were （0.044 ± 0.003）h^-1 and （3.47±0.64）% while those of berberine mixed with baicalin were （0.057 ± 0.006） h^-1 and （5.18 ± 0.83）%, respectively. There were significant difference in the absorption rate constant of baicalin after mixing （P〈 0.05）. Meanwhile there were significant difference in the absorption rate constant and absorption rate of berberine （P〈0.05）. CONCLUSION： Baicalin can promote the absorption of berberine while berberine can inhibit the absorption of baicalin.

关 键 词：黄芩苷 盐酸小檗碱 吸收动力学 相互作用 

分 类 号：R285[医药卫生—中药学] R284[医药卫生—中医学]