肺移植后闭塞性支气管炎与支气管上皮细胞的作用  

Association between tracheal epitheliums and bronchitis obliterans following lung transplantation

作　　者：张瑜[1] 韩彪[1] 

机构地区：[1]兰州大学附属第一医院胸外科,甘肃省兰州市730000

出　　处：《中国组织工程研究与临床康复》2010年第5期911-914,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：肺移植是目前治疗终末期肺病的惟一有效方法,而闭塞性支气管炎是阻止肺移植长期存活的最主要并发症,其中支气管上皮细胞是引起这种迟发性排斥反应的主要靶器官。文章主要简要阐述了闭塞性支气管炎发生、发展中的免疫机制以及支气管上皮细胞在此过程中的作用和研究中的进展,其目的是初步讨论支气管上皮细胞与闭塞性支气管炎的紧密关系,使人们更加关注终末期肺疾病患者肺移植的研究,希望找到解决肺移植长期生存的方法。Lung transplantation is the only effective treatment for final stage pneumonopathy.However,bronchitis obliterans,as the main of complication,can prevent the long term survival after lung transplantation.Tracheal epithelium cell is the main target organ of the tardive reject reaction.This paper briefly explains the immunologic mechanism regarding the development of bronchitis obliterans,and the role of tracheal epithelium cell in the study,with aim of exploring the initial relationship between tracheal epithelium cell and bronchitis obliterans,and to find a method to solve the long-term survival of lung transplantation.

关 键 词：支气管上皮细胞 闭塞性支气管炎 肺移植 免疫 

分 类 号：R617[医药卫生—外科学]