骨髓细胞输注诱导的免疫耐受  

Immune tolerance induced by bone marrow cell infusion

作　　者：叶明佶[1] 谢续标[1] 彭龙开[1] 

机构地区：[1]中南大学湘雅二医院泌外器官移植科,湖南省长沙市410011

出　　处：《中国组织工程研究与临床康复》2010年第5期915-918,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:综述国内外关于骨髓细胞输注诱导免疫耐受的研究概况。方法:应用计算机检索PubMed2000-01/2008-12期间的相关文章,检索词为"bone marrow cells,transplantation immune tolerance",并限定文章语言种类为English。同时计算机检索中国生物医学文献数据库、中国期刊全文数据库2000-01/2008-12期间相关文章,检索词为"骨髓细胞,免疫耐受",并限定文章语言种类为中文。此外还手工查阅《器官移植学》、《移植免疫耐受》,以及相关的中英文会议论文集。纳入标准:①形成免疫耐受的相关机制。②骨髓细胞输注诱导免疫耐受的方案。③骨髓细胞输入诱导免疫耐受的优、缺点。④同一领域选择近期发表或在权威杂志上发表的文章。排除标准:重复性研究或不切题文章。结果:免疫耐受的产生机制主要有清除、无能、调节或抑制、忽略等。骨髓细胞输注诱导免疫耐受的方案主要有骨髓细胞输注联合清髓性预处理、骨髓细胞输注联合非清髓性预处理、应用免疫抑制药物或化疗药物为主的预处理、以共刺激信号系统阻断为主的预处理、骨髓细胞联合间充质干细胞输注等。骨髓细胞输注诱导免疫耐受通过有效的免疫耐受机制可诱导形成持久稳定的特异免疫耐受,成为目前诱导移植耐受最为有效、最主要的方法。结论:到目前为止,临床免疫耐受仍然是不可控制的和偶发的。通过骨髓细胞输注诱导稳定的免疫耐受,必将为器官移植开辟新的天地。OBJECTIVE：To summarize the study of bone marrow cell infusion-induced immune tolerance.METHODS：The Pubmed database was researched using the computer for articles published from January 2000 to December 2008 using the of ＂bone marrow cells,transplantation immune tolerance＂ in English.Simultaneously,Chinese Biomedical Literature Database and China Journal Full-text Database were retrieved for articles published from January 2000 to December 2008 using the key words of ＂bone marrow cells,immune tolerance＂ in Chinese.Besides,Organ Transplantation,Transplantation Immune Tolerance and Conference Proceedings of English and Chinese were retrieved by hand.Inclusion criteria relevant mechanism of immune tolerance;scheme of bone marrow cell infusion-induced immune tolerance;advantages and disadvantages of bone marrow cell infusion-induced immune tolerance;articles in the same circle published in recent years or in authorized journals.Exclusion criteria：repetitive studies or irrelevant articles. RESULTS：Mechanism of immune tolerance comprised cleaning,inability,regulation or inhibition,and ignorance.The scheme of bone marrow cell infusion-induced immune tolerance mainly contained bone marrow cell infusion combined with myeloablative pretreatment,bone marrow cell infusion combined with non-myeloablative pretreatment,pretreatment with immunosuppressive drug or chemotherapeutics,pretreatment of costimulatory signaling blockage,bone marrow cell combined with mesenchymal stem cell infusion.Bone marrow cell infusion-induced immune tolerance could induce long-lasting stable specific immune tolerance by effective immune tolerance mechanism,and had been an effective main method for inducing transplanted tolerance.CONCLUSION：Up to now,clinical immune tolerance is still uncontrollable and facultative.Bone marrow cell infusion-induced stable immune tolerance can develop a new space for organ transplantation.

关 键 词：免疫耐受 嵌合体 骨髓细胞 器官移植 移植耐受 

分 类 号：R318[医药卫生—生物医学工程]