维吾尔族人汉字语义联想任务的功能MRI研究  

Cerebral activation during Chinese semantic associative task in Xinjiang＇Uyghurs： a functional MRI study

作　　者：杨利霞[1] 贾文霄[2] 汤伟军[3] 王红[2] 丁爽[1] 王皓[2] 

机构地区：[1]新疆医科大学第一附属医院影像中心,乌鲁木齐830054 [2]新疆医科大学第二附属医院影像中心 [3]复旦大学附属华山医院放射科

出　　处：《中华放射学杂志》2010年第3期239-242,共4页Chinese Journal of Radiology

基　　金：国家自然科学基金资助项目（30760062）

摘　　要：目的运用fMRI探讨以汉语为第二语言的维吾尔族人，对汉字进行阅读联想时，与汉族人大脑激活区域的差异。方法选取21名健康维吾尔族人与11名健康汉族人进行fMRI。fMRI采用BOLD组块设计，受试者接受单个汉字任务视觉刺激，所得原始图像数据经统计参数图（SPM）5脑功能MR图像处理软件包处理，生成受试者的脑激活图，并进行对照研究，分析维吾尔族人和汉族人脑激活空间分布上的差异。结果维吾尔族人与汉族人汉字任务主要激活了左侧额中回和额下回（BA9、47）、颞中回（BA37）皮层、顶上下小叶（BA7、40），双侧视觉系统（BAs17—19）及小脑，两个民族受试者激活区域基本一致，但维吾尔族人的脑激活范围明显大于汉族人。结论母语为维吾尔语者，其汉字脑处理过程与汉族人激活区域基本一致，但需要更多的脑区来参与和完成；其脑激活范围明显大于汉族人。Objective To explore the cerebral activation in Xinjiang＇ Uyghurs when performing a Chinese word tasks by the functional magnetic resonance image （fMRI）. Methods Twenty-one healthy Xinjiang＇ Uyghurs and 11 healthy Hans were scanned using functional magnetic resonance imaging （fMRI） on a 1.5 T MRI scanner with a single run. Different Chinese words were displayed in each block to avoid any practice effect. SPM5.0 software was used for image data processing. To evaluate the inter subject consistency of brain activations associated with Chinese character and word reading, we created penetrance maps by combining binary individual functional maps. Results For Uyghur-Chinese bilingual subjects, activations related to generated a word that was semantically related to each stimulus. The results indicated that reading Chinese is characterized by extensive activity of the neural systems. Peak activations occurred in the left middle frontal cortex at Brodmann Areas（ BA9 and BA 47）. The left temporal（ BA 37）cortices were also strongly activated. Other important activated areas included bilateral visual systems （ BA 17-19） and cerebellum. The location of peak activation in the left frontal regions was similar in Native Uyghurs and Hans. But the active areas in Uyghurs are more extensive than that of Hans. Conclusions The location of peak activation in the left frontal regions was similar in Native Uyghurs and Hans. More brain areas were needed for Xinjiang＇ Uyghur speakers during processing Chinese words.

关 键 词：维吾尔族 语言 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]