基于统计参数图的MRI海马结构体积测量  

MRI volumetric measurement of hippocampal formation based on statistic parametric mapping

作　　者：华建明[1] 蒋飚[1] 周炯[2] 章伟敏[1] 

机构地区：[1]浙江大学医学院附属第二医院放射科,杭州310009 [2]浙江大学医学院附属第二医院神经内科,杭州310009

出　　处：《中华放射学杂志》2010年第3期294-297,共4页Chinese Journal of Radiology

基　　金：浙江省科技厅重点科研资助项目（2006C23030）;浙江省卫生厅科研资助项目（20078089）

摘　　要：目的研究经统计参数图（SPM）软件分割分析处理净灰质脑海马结构体积测量方法，并探讨这种基于体素的海马体积测量法在阿尔茨海默病（AD）诊断中的价值。方法选取15例AD患者（AD组）和15名健康志愿者（正常对照组）行MR检查，利用SPM软件分割分析功能，将标准三维MR颅脑图像分离为独立的灰、白质和脑脊液图谱，在净灰质脑中分别勾画测量AD组和正常对照组左、右两侧海马结构体积，并与作为体积测量金标准的传统手工描绘ROI测量法比较，同时记录两种测量方法在每例海马边界描绘及体积计算的平均用时。采用独立样本配对t检验进行两种测量方法所得体积、平均用时的均数比较。另外，由7名影像医师对同一例正常对照者采用上述两种方法分别测量其左侧海马结构体积，采用变异系数比较两种测量方法所得数据的频数分布及离散程度。结果（1）经SPM处理测量法测定AD组的左、右两侧海马平均体积分别为（1．88±0．07）和（1．93±0．08）cm^3，对照组分别为（2．99±0．07）和（3．02±0．06）cm^3；ROI测量法测定AD组分别为（1．87±0．06）和（1．91±0．09）cm^3，对照组则为（2，97±0．08）和（3．00-4-0，05）cm^3。经SPM处理测量法在AD组及正常对照组测定结果与传统ROI测量法之间差异均无统计学意义（t值分别为1．500、1．617、1．095、1．889，P值均〉0．05）。每例描绘边界、计算体积平均用时经SPM处理测量法为（38．1±2．0）min，ROI测量法为（55．4±2．4）min，两者之间差异有统计学意义（t=-25．918，P〈0．01）。（2）7名医师对同一例正常对照者采用经SPM处理测量法和ROI测量法测得左侧海马平均体积分别为（2．86±0．20）和（2．76±0．52）cm^3；变异系数分别是7％、19％，两种方法测定海马体积的频数分布存在差别。结论利用SPM软件的图像分割分�Objective To study MRI volumetric measurement of hippocampal formation using statistic parametric mapping（SPM） software and to discuss the value of the method applied to Alzheimer＇s disease （AD）. Methods The SPM software was used to divide the three-dimensional MRI brain image into gray matter, white matter and CSF separately. The bilateral hippocampal formations in both AD group and normal control group were delineated and the volumes were measured. The SPM method was compared with conventional method based on region of interest （ROI）, which was the gold standard of volume measurement. The time used in measuring the volume by these two methods were respectively recorded and compared by two independent samples＇ t test. Moreover, 7 physicians measured the left hippocampal formation of one same control with both of the two methods. The frequency distribution and dispersion of data acquired with the two methods were evaluated using standard deviation coefficient. Results （ 1 ） The volume of the bilateral hippocampal formations with SPM method was （ 1.88 ± 0. 07 ） cm3 and （ 1.93± 0. 08 ） cm3 respectively in the AD group, while was （2. 99 ±0. 07） cm3 and （3.02 ±0. 06）cm3 in the control group. The volume of bilateral hippocampal formations measured by ROI method was （ 1.87 ± 0. 06 ） cm3 and （1.91 ±0. 09） cm3 in the AD group, while was （2. 97 ±0. 08）cm3 and （3.00 ±0. 05） cm3 in the control group. There was no significant difference between SPM method and conventional ROI method in the AD group and the control group （ t =1. 500, 1. 617, 1. 095, 1. 889, P 〉 0. 05 ）. However, the time used for delineation and volume measurement was significantly different. The time used in SPM measurement was （38.1 ±2.0） min, while that in ROI measurement was （55.4 ±2.4） min （t = -25.918, P 〈0.01）. （2）The average volumes of the left hippocampal formation with the two methods measured by the 7 physicians were （2. 86 ± 0. 20 ） and （2. 76 ± 0. 52 ）

关 键 词：海马 磁共振成像 人体测量术 

分 类 号：R445.2[医药卫生—影像医学与核医学]