高本底放射性饮水对小鼠血清SOD和MDA水平的影响  

Effects of drinking water with high background radiation on serum SOD and MDA levels of mice

作　　者：冯国清[1,2,3] 付润芳[1,2,3] 吕文戈 程学敏[1,2,3] 巴月 王晓[1,2,3] 郜金社 贾思远[1,2,3] 耿民学 邬明莉[1,2,3] 

机构地区：[1]河南医科大学药理学教研室 [2]河南医科大学环境卫生学教研室 [3]平顶山煤业集团卫生防疫站

出　　处：《河南医科大学学报》1998年第4期62-64,共3页Journal of Henan Medical University

基　　金：平顶山煤业集团资助

摘　　要：昆明种小白鼠３６只随机分成３组，分别饮用自来水、八矿饮用水和康冷矿泉水１００ｄ和１５０ｄ后取股动脉血进行血清ＳＯＤ和ＭＤＡ水平测定。结果：１００ｄ时八矿饮用水组小鼠血清中的ＳＯＤ和ＭＤＡ含量均低于自来水组而高于康冷矿泉水组（８５６０±１５１１＞７２２２±９３０＞５４６６±１５６３Ｕ·ｍｌ－１；９２．６０±３８．０５＞８６．６７±３４．１１＞５１４４±２３．７１μｍｏｌ·ｍｌ－１），１５０ｄ时亦显示同样趋势，但经统计处理，八矿饮用水与自来水间差异无显著性，与康冷矿泉水组相比则差异有显著性（Ｐ＜００５）。提示：一定剂量范围的高放射性饮水对实验动物血清的ＳＯＤ和ＭＤＡ含量无明显影响。Kunming mice were randomly divided into 3 groups,drinking tap water and two high background radiation drinking water (Bakuang drinking water and Kangleng mineral spring water),respetively.At the end of 100 and 150 days,samples were collected for the detection of serum SOD and MDA levels of mice.The results showed that at the end of 100 days the serum SOD and MDA levels of Bakuang drinking water mice were lower than those of tap water group(no significant difference),and higher than those of Kangleng mineral spring water group ( P <0 05) At the end of 150 days,the similar results were observed.The results suggest that the higher radiation can significantly decrease the serum SOD and MAD levels of mice.

关 键 词：高本底放射性 饮水 SOD MDA 血清诊断 

分 类 号：R446.112[医药卫生—诊断学] R123.5[医药卫生—临床医学]