周期蛋白依赖激酶抑制因子p21^(WAF1/CIP1)在银屑病表皮中高表达  

Overexpression of p21^(WAF1 CIP1)——inhibitor of Cyclin-Dependent Kinase in Psoriatic Epidermis

作　　者：张晓艳[1] 马圣清[1] 柳惠图[2] 

机构地区：[1]北京医科大学第一临床学院皮肤科 [2]北京师范大学生物系

出　　处：《中华皮肤科杂志》1998年第6期363-365,共3页Chinese Journal of Dermatology

基　　金：国家自然科学基金(39388002;39200024)

摘　　要：目的探讨 p21~与银屑病发病的关系。方法通过核酸杂交和免疫组织化学的方法检测了12例斑块型银屑病和5例正常人表皮中 p21~的表达。结果银屑病表皮中 p21~的表达位于表皮全层,较正常表皮明显增强,正常人表皮中其表达位于表皮上部。结论 p21~可能与正常表皮细胞的分化关系更密切,在银屑病表皮细胞的异常分化调节中可能发挥作用。Objective To observe the relationship between p21and development of psoriasis. Methods The expression of p21in twelve psoriatic and five normal epidermis was studied by dot hy- hridization,in situ hvbridization and immunohistochemistry.Results In psoriatic epidermis,the expression of p21,was in whole layers of epidermis,and was significantly inereased eompared with that of normal skin. In normal epidermis,its expression was in upper laver of epidermis.Conclusion These results indicate thai p21might be assoeiated with differentiation of normal keralinoevtes and might play a role in abnormal differentiation of psoriatic keratonoeyles.

关 键 词：银屑病 p^21WAF1/CIP1 核蛋白 

分 类 号：R758.630.2[医药卫生—皮肤病学与性病学]