米诺地尔对培养鼠触须毛囊生长的影响  

Study on the Effect of Minoxidil on Mouse Vibrissae Follicles in Vitro

作　　者：傅琳玲[1] 朱文元[1] 范卫新 

机构地区：[1]南京医科大学第一附属医院皮肤科,南通医学院附属医院皮肤科210029

出　　处：《中华皮肤科杂志》1998年第6期371-372,共2页Chinese Journal of Dermatology

摘　　要：目的 体内米诺地尔临床应用引起多毛，局部外用治疗秃发有效。方法 采用Ｃ５７ＢＬ／６Ｊ近交系乳鼠触须毛囊培养、毛囊显微形态观察及＾３Ｈ－ＴｄＲ同位素标记掺入等技术，研究在体外不同浓度米诺地尔在不同培养时间条件下对毛囊生长的影响。结果 米诺地尔浓度７０μｇ／ｍｌ，培养２４小时，毛囊生长较快。毛囊形态学改变毛乳头松散，毛球部扩大，毛母质细胞增生活跃。培养４８小时，毛囊生长明显减慢。培养３０小时，＾３Ｈ－Objective To study the effect of minoxidil on the growth of hair follicles.Methods Organ cuhure of new-born mouse vibrissa follicles in vitro.incorportating of ~3H-TdR radioaetive thymidine into the cultured follieles and the histopathologic features of the follicles.Results When the the follieles were eultured in 701μg/ml of minoxidil for 24h.the follicles had a signifieanl inerease in length,the hair dermal papilla loosned. the follicle bulb enlarged,and the matrix cells grew actively,when cultured for 48h.Ihe rate of increase of the length of the follicles reduced.When cultured for 30h.there was a signfieant increase of ~3H-TdR incorporating. Conclusion The results indieate thai minoxidil promotes the growth of hair follicles,and is related to its COD- centration and the duration of culture of the follieles.

关 键 词：米诺地尔 组织培养 秃发 药物疗法 毛囊生长 

分 类 号：R758.710.5[医药卫生—皮肤病学与性病学]