B1淋巴细胞与相关疾病研究新进展  

Advances in the research of B1-cell and its relationship with diseases

作　　者：赵菁[1] 周韧[1] 

机构地区：[1]浙江大学医学院病理学与病理生理学系,浙江大学病理与法医研究所,杭州310058

出　　处：《国际免疫学杂志》2010年第2期114-116,120,共4页International Journal of Immunology

基　　金：国家自然科学基金女助项目（30670810）;浙江省卫生厅科研基金资助项目（2006A084）

摘　　要：B1细胞是一种表型和功能上都有别于传统意义上B细胞（B2细胞）的独特的B细胞群。它分泌多种类型的自身抗体，主要参与固有免疫反应。长期以来，B1细胞与B2细胞的来源一直具有争议，最近，B1细胞前体和B2细胞前体已经在小鼠体内得到分离，B1细胞发育分化的调节机制也随之建立起来。目前B细胞的分类已经明确：根据来源的不同将B细胞分为非骨髓来源的B1细胞和骨髓来源的B2细胞。其中，表达CD5的B1细胞由于其与自身免疫病、恶性肿瘤的关系受到了广泛关注，因而其相关作用机制也越来越受到学者们的重视。B1 cell, a unique subset of B cell, is different from traditional B cell （ B2 cell）. B-1 B cells have been considered to be part oft he imate immune system, whereas B-2 B cells function primarily in adaptive immune responses. It has been acoutroversial issue about the origin of B-1 and B-2 B ceils. Rencently,experimental data from murine studies support the hypothesis that B-1 B cells belong to a developmental lineage distinct from B-2 B cells. It is dear that B cell can be divided into two subsets：B1 cell and B2 cell. CD5^ ＋ B1 cell is related to autoimmune diseases and tumor. This review draws attention to the recent advance on the study of B-1 subset in terms of cell development ,function,and the relationship with diseases.

关 键 词：B淋巴细胞亚群 自身免疫性疾病 慢性B淋巴细胞性白血病 

分 类 号：R3[医药卫生—基础医学]