不同方法治疗婴幼儿社区获得性肺炎临床研究  

Clinical Research of Infants with Community-acquired Pneumonia by Different Treatment Methods

作　　者：郭乃火[1] 楚建元[1] 李小珍[1] 亓华云[2] 

机构地区：[1]广东省深圳市龙岗中心医院社康科,广东深圳518116 [2]广东省深圳市龙岗中心医院手术室,广东深圳518116

出　　处：《中国现代医生》2010年第9期104-105,共2页China Modern Doctor

摘　　要：目的探讨婴幼儿社区获得性肺炎(CAP)不同治疗方法的临床疗效和不良反应。方法100例社区获得性肺炎随机分为阿奇霉素组(A组)50例和头孢呋辛钠组(B组)50例;采用VITEK-AMS微生物分析仪测定病原菌,并用纸片法(Kir-by-Bauer)测定病原菌的体外药物敏感性。结果A组治疗后痊愈45例(90.0%)明显高于B组39例(78.0%);A组退热时间(3.86±0.95)d低于B组(5.01±1.12)d;A组啰音消失时间(3.81±0.74)d低于B组(5.17±1.22)d,差异均有统计学意义(P<0.05)。A组阳性株数44株,转阴株数39株,细菌消除率为88.6%;B组阳性株数41株,转阴株数35株,细菌消除率为85.3%;A组3例出现恶心、呕吐,不良反应发生率为6.0%(3/50),B组为8.0%(4/50),差异均无统计学意义(P>0.05)。结论阿奇霉素是治疗婴幼儿CAP的首选药物。Objective To investigate the infants with community-acquired pneumonia（CAP）of different treatment methods of clinical effica- cy and adverse reactions. Methods 100 cases of community-acquired pneumonia were randomly divided into azithromycin group（A group） 50 cases and eefuroxime sodium group （B group ） 50 eases ; using VITEK-AMS microbiological analysis to measure the pathogens, and use disk diffusion method （Kirby-Bauer）Determination of pathogenic bacteria in vitro drug sensitivity. Results A group after treatment cured 45 cases （90.0%）was significantly higher than the B group of 39 eases（78.0%）（ χ 2=3.98 ,P〈0.05） ;The time in A group defervescence（3.86 ＋ 0.95）days less than the B group（5.01 ± 1.12）days（t=2.416, P〈0.05）;The time rales disappearance in group A（3.81 ± 0.74）days less than B group （5.17 ± 1.22）days（ t= 2.396, P〈0.05 ）;The positive in group A of 44 strain, turin negative in 39 strain, bacterial eradication rate was 88.6%; The positive in group B 41 strain,turin negative in 35 strain,bacterial eradication rate was 85.3%,A,B groups of bacteria elimination was no significant difference （χ 2=2-98,P〉0-05） ;The incidence of adverse reactions of nansea,vomifing in group A of 3 eases 6.0%（3/50）;B group was 8.0% （4/50）（ χ 2= 2.23, P〉 0.05 ）. Conclusion The drug of Azithromycin were preferred with treatment in infants and young with CAP.

关 键 词：社区获得性肺炎 婴幼儿 疗效 不良反应 

分 类 号：R563.1[医药卫生—呼吸系统]