8-异前列腺素F2а与早期糖尿病肾病关系的临床研究  

Study of clinic significance and the relationship between plasma 8-iso-prostaglandin F2а and early stage diabetic nephropathy

作　　者：裴薇[1] 逄力男[2] 柳林[2] 吴琰[1] 张金华[1] 

机构地区：[1]潍坊医学院,261042 [2]潍坊市人民医院内分泌科

出　　处：《中国实用医药》2010年第8期6-8,共3页China Practical Medicine

摘　　要：目的探讨血浆8-异前列腺素F2а(8-iso-prostaglandin F2α,8-isoPGF2α)水平与早期糖尿病肾病的关系及临床意义。方法选择2型糖尿病患者63例,分为单纯糖尿病组(22例)和早期糖尿病肾病组(41例);以同期健康查体者31例作为正常对照组,用ELISA法检测3组血浆8-isoPGF2а水平,并进行统计学分析。结果单纯糖尿病组、早期糖尿病肾病组和对照组患者血浆8-isoPGF2а水平分别为(394.5±104.1)pg/ml、(562.7±211.8)pg/ml和(292.7±66.7)pg/ml,组间比较差异有统计学意义(F=13.907,P<0.001)。与对照组比较,单纯糖尿病组及早期糖尿病肾病组8-isoPGF2а水平显著升高,差异有统计学意义(P<0.05,P<0.001);与单纯糖尿病组比较,早期糖尿病肾病组8-isoPGF2а水平明显升高,差异有统计学意义(P=0.001)。血浆8-isoPGF2а水平与HbA1c呈显著正相关(r=0.349,P=0.012)。结论2型糖尿病肾病早期氧化应激水平明显增加,检测血浆8-isoPGF2а水平对于预测早期糖尿病肾病可能具有一定临床意义。Objective To study the relationship between plasma 8-isoPGF2α and early stage diabetic nephropathy and analyze it＇s clinic significance.Methods 63 patients with type 2 diabetes mellitus （DM） were divided into 2 groups according to the value of urinary albumin excretion rate （UAER）：①simple DM group （SDM,UAER20μg/min）,22 cases;②early diabetic nephropathy （EDN,UAER20～200μg/min）,41 cases.The plasma level of 8-isoPGF2αwas measured in the type 2 DM patients of 2 groups and 31 normal controls（NC）by ELISA.Results ①The plasma level of 8-isoPGF2α in patients with SDM,EDN and NC groups were（394.5±104.1）pg/ml、（562.7±211.8）pg/ml and（292.7±66.7）pg/ml,respectively.Significant difference was found among the 3 groups （F=13.907,P〈0.001）②Compared to NC group,the level of 8-isoPGF2αwas markedly high in SDM and EDN groups （P〈0.05,P〈0.001）.Further more,the level of 8-isoPGF2αwas higher in EDN than SDM （P=0.001）③ There was a significant positive correlation between 8-isoPGF2αand HbA1c（r=0.349,P=0.012）.Conclusion The plasma level of 8-isoPGF2αwas significantly elevated in EDN.Measurment of plasma 8-isoPGF2αseems to be helpful for early diagnosis of diabetic nephropathy.

关 键 词：2型糖尿病 糖尿病肾病 8-iso-prostaglandin F2а 氧化应激 

分 类 号：R587.2[医药卫生—内分泌]