3种方案治疗儿童原发性遗尿症的药物经济学分析  

Pharmacoeconomic Analysis on 3 Therapeutic Regimens for Primary Nocturnal Enuresis in Children

作　　者：熊一岚[1] 万力生[1] 

机构地区：[1]深圳市儿童医院,深圳市518026

出　　处：《中国医院用药评价与分析》2010年第3期254-256,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨3种方案药物治疗儿童原发性夜间遗尿症的经济效果。方法:152例患儿随机分为3组,分别给予醋酸去氨加压素(A组)、醋酸去氨加压素合并奥昔布宁(B组)和酸酸去氨加压素合并中药温肾止遗汤(C组)3种不同方案治疗。运用药物经济学中最小成本分析法(CMA)进行评价。结果:3种方案在临床疗效、不良反应发生率等方面无显著差异(P>0.05);药物治疗费用以B方案最低;而A方案复发率最高,与B、C两方案比较有显著差异(P<0.05)。结论:醋酸去氨加压素合并奥昔布宁治疗方案复发率较低,成本低,更具经济学优势,而醋酸去氨加压素合并中药温肾止遗汤方案虽成本较高,但复发率最低,远期疗效理想。OBJECTIVE： To evaluate the pharmacoeconomic efficacy of 3 therapeutic schemes for primary nocturnal enuresis （PNE） in children. METHODS： A total of 152 PNE case were randomly divided into 3 groups： Group A received Desmopressin,Group B Desmopressin combined Oxybutynin and group C Desmopressin combined Wenshenzhiyi Tang （kidney - warming enuresis - arresting Chinese medicinal decoction）. The 3 schemes were evaluated using cost - minimization analysis （CMA） in pharmacoeconomics. RESULTS： There were no significant differences （P〈0. 05） across the 3 schemes in clinical efficacy and adverse drug reactions. Scheme B had the lowest treatment cost,while scheme A showed the highest recurrence rate compared with the other two schemes （ P〈0. 05）. CONCLUSION： Treatment of primary nocturnal enuresis （PNE） in children with Desmopressin combined Oxybutynin is optimal for its lower cost the lower recurrence rate; however,Desmopressin （ Minirin） combined Chinese medicinal decoction （Wenshenzhiyi Tang） involved the lowest recurrence rate and ideal long -term efficacy despite its higher cost.

关 键 词：儿童原发性遗尿症 去氨加压素 奥昔布宁 中药汤剂 药物经济学 

分 类 号：R965[医药卫生—药理学]