阵发性心房颤动患者射频导管消融后超敏C反应蛋白变化的随访研究  

Change of C-reactive Protein After Catheter Ablation of Paroxysmal Atrial Fibrillation

作　　者：李恒栋[1] 江隆福[1] 陈玉峰[1] 王虹[1] 

机构地区：[1]浙江省宁波市第二医院心内科,315010

出　　处：《心电学杂志》2010年第2期117-119,共3页Journal of Electrocardiology(China)

摘　　要：目的随访阵发性心房颤动患者经射频导管消融（下称消融）后以超敏C反应蛋白（CRP）的变化来评价心房颤动与炎症之间的关系和消融治疗的疗效。方法选取25例有明显症状，经药物治疗无效的阵发性心房颤动患者，在三维电解剖标测系统（Carto）指导下行环肺静脉线性消融术（CPVA），消融终点为同侧肺静脉电隔离，检测心房颤动患者术前、术后1d、1周、1月、3月时的超敏C反应蛋白水平，并随访心电图观察疗效。对照组为30例健康体检者。结果阵发性心房颤动患者术前CRP浓度较对照组显著增高（P〈001），维持窦性心律者术后1周内升高，随之逐渐降至正常水平，但心房颤动复发患者CRP浓度无明显下降。结论炎症是心房颤动的原因之一，可促进心房颤动的发生和发展，消融治疗心房颤动安全有效。Objective To assess the relationship between inflammation and atrial fibrillation （AF） based on changes of C-reactive protein （CRP） after ablation of paroxysmal AF. Methods 25 patients with paroxysmal AF underwent circumferential pulmonary vein ablation （CPVA）. The endpoint of the procedure was electrical isolation of ipsilateral pulmonary vein. Serum CRP was measured before ablation and 1 day, 1 week, 1 month and 3 months after ablation and compared to that of 30 healthy subjects. Electrocardiogram was recorded during follow-up to evaluate therapeutic efficacy. Results Serum CRP level was significantly higher in patients with AF than that in healthy subjects （P 〈 0.01 } at baseline and increased within one week after CPVA. Then, serum CRP gradually returned to normal level in patients maintaining sinus rhythm but changed little in patients with AF recurrence. Conclusion Inflammation may be one of causes and related to occurrence and progress of AF.

关 键 词：阵发性心房颤动 射频导管消融 C反应蛋白 

分 类 号：R541.75[医药卫生—心血管疾病]