含锶硼硅酸盐生物玻璃的降解性能及体外生物活性  

Research of borosilicate glass with strontium on bioactivity and biodegradability in vitro

作　　者：赵寅生[1] 张欣[1] 向卫东[1] 王德平[1,2] 黄文旵[1] 潘浩波[3] 吕维加[3] 

机构地区：[1]同济大学材料科学与工程学院生物与信息材料研究所,上海200092 [2]同济大学教育部先进土木工程材料重点实验室,上海200092 [3]香港大学李嘉诚医学院,香港999077

出　　处：《功能材料》2010年第3期439-442,共4页Journal of Functional Materials

基　　金：上海市科委生物医学领域重点攻关资助项目(08441900500)

摘　　要：研究了含锶硼硅酸盐玻璃的体外生物活性和降解性。采用熔融法制备不同锶含量(SrO含量为0、2%、4%、6%、8%、10%、12%(摩尔分数))的硼硅酸盐生物玻璃粉末,粒径范围为150～300μm。将各组玻璃样品浸泡在0.02mol/L的K2HPO4溶液中,置于37℃恒温条件下,进行体外生物矿化反应。通过对反应样品的质量损失以及浸泡液pH值进行测定,并用XRD、FTIR以及SEM对反应过程和反应后产物进行表征。结果表明,含锶的硼硅酸盐玻璃在体外生物矿化反应中被生物降解,并转化为含锶羟基磷灰石,具有很好的生物活性和降解性;同时也观察到玻璃中引入锶元素后,在一定程度上控制玻璃的降解速度,进而控制硼的溶出速度,从一定程度上避免硼溶出速度过高可能带来的风险;ICP的结构也表明,当SrO为6%(摩尔分数),样品中硼元素溶出的速度最低。因此,用锶的含量可控制硼硅酸盐玻璃的降解速度,这种方法将在组织工程领域具有广阔的应用前景。The bioactivity and biodegradability of the borate-based glasses containing different strontium contents（n（Sr）=0,2%,4%,6%,8%,10%,12mol%） were investigated inthis paper.The glass particles with the size of 150-300μm were prepared by a melting process,then the samples were immersed in 0.02mol/L K2HPO4 solution at 37℃ to research their properties of bioactivity and biodegradability.During the immersion experiment,the mass loss and pH value were measured.And the XRD and SEM were used to characterize the conversed products.The results prove that the Sr-borosilicate bioactive glasses have good biodegradability and bioactivity;in the K2HPO4 solution,they can converse to Sr-HA.SrO introduced into the borosilicate bioactive glass can change the degradation of the glass.This means the borate releasing from the glass can be controlled through the change of the strontium oxide content,therefore,the toxic of borate can be to avoided to some extent.When n（SrO）=6mol% in the composition,the degradation rate are the lowest,and the borate releasing from the glass is at the minimum.Consequently,the Sr-borosilicate bioactive glass show potential application in bone tissue engineering.

关 键 词：氧化锶 硼酸盐生物玻璃 生物降解性 生物活性 

分 类 号：TB321[一般工业技术—材料科学与工程]