睡眠呼吸暂停综合征合并高血压与胰岛素抵抗的研究  

Obstructive sleep apnea syndrome complicated by hypertension and insulin resistance

作　　者：黎晓晖[1] 钱小顺[1] 李天志[1] 李金明[1] 孙宝君[1] 刘长庭[1] 

机构地区：[1]解放军总医院南楼呼吸科,北京100853

出　　处：《军医进修学院学报》2010年第4期339-340,共2页Academic Journal of Pla Postgraduate Medical School

基　　金：解放军总医院苗圃基金项目(06MP50)

摘　　要：目的观察OSAS合并高血压患者体内炎症水平和胰岛素抵抗的关系。方法用PSG检查确诊重度OSAS患者70例,其中40例合并高血压病。用全自动生化仪检测血清真胰岛素(FINS)、C肽、C反应蛋白、空腹血糖,用稳态模型(HOMA)计算IR指数和胰岛β细胞功能指数。结果OSAS合并高血压患者血清CRP、FINS、血清C肽、HOMA-IR和HOMA-islet均较单纯OSAS患者明显升高。结论OSAS患者的慢性炎症通过形成胰岛素抵抗,在OSAS合并高血压的过程中可能起重要作用。Objective To observe the correlation between in vivo inflammation severity and insulin resistance in obstructive sleep apnea syndrome （OSAS） patients with hypertension. Methods Of the 70 severe OSAS patients diagnosed with PSG, 40 were found to be complicated by hypertension. Serum FINS, peptide C and CRP levels were measured using a fully automatic biochemical device. Homeostasis model assessment was used to calculate the insulin resistance （IR） index and the function index of isletβcells. Results The serum levels of true insulin, peptide C, CRP, IR index, function index of isletβcells were higher in OSAS patients with hypertension than in those without hypertension. Conclusion Chronic inflammation may play a role in the development of hypertension in OSAS patients due to formation of insulin resistance.

关 键 词：睡眠呼吸暂停综合征 炎症 胰岛素抵抗 高血压 

分 类 号：R56[医药卫生—呼吸系统]