白藜芦醇对兔动脉粥样硬化基质金属蛋白酶表达的影响  

Effect of resveratrol on expression of matrix metalloproteinase in rabbits with athrosclerosis

作　　者：李运田[1] 柳杨[1] 杜大勇[1] 王芳[1] 

机构地区：[1]解放军第305医院全军冠心病诊疗中心,北京100017

出　　处：《军医进修学院学报》2010年第4期356-357,366,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：全军"十一.五"医药卫生科研基金项目(06G145)~~

摘　　要：目的探讨白藜芦醇对实验性动脉粥样硬化兔基质金属蛋白酶(MMP)表达的影响。方法选择新西兰纯种雄性大白兔50只随机分为三组,正常对照组10只,模型组20只,白藜芦醇组20只。采用液氮冻伤术建立动脉硬化模型,造模2个月后采用液氮冻伤术激发动脉硬化斑块破裂,模后2个月及激发试验后48h后分别对三组动物测定MMP-1、9的浓度。结果模型组造模后2个月MMP-1、9的浓度分别为(50.74±5.49)ng/ml和(337.69±8.98)ng/ml,同期白藜芦醇组MMP-1、9的浓度分别为(41.33±9.58)ng/ml和(309.83±10.59)ng/ml(P<0.01),激发试验48h后模型组MMP-1、9的浓度分别为(100.35±6.58)ng/ml和(869.56±12.37)ng/ml,同期白藜芦醇组MMP-1、9的浓度分别为(61.68±11.69)ng/ml和(411.24±15.74)ng/ml(P<0.01)。结论白藜芦醇能够降低MMP-1、9的浓度,从而预防和延缓动脉硬化的发生。Objective To study the effect of resveratrol on expression of matrix metalloproteinase （MMP） in rabbits with experimental atherosclerosis. Methods Fifty New Zealand healthy rabbits were randomly divided into normal control group（n=10）, atherosclerosis model group（n=20）, and resveratrol group（n=20）.Two months after an atherosclerosis model was established using liquid nitrogen, cold injury was induced to provoke rupture of atherosclerosis plaque. Levels of MMP-1 and 9 were measured 2 months after model establishment and 48 hours after provocation test, respectively. Results The levels of MMP-1 and 9 were 50.74±5.49ng/ml and 337.69±8.98ng/ml in model group and 41.33±9.58ng/ml and 309.83±10.59ng/ml in resveratrol group, respectively, 2 months after model establishment（P0.01）, while they were 100.35±6.58ng/ml and 869.56±12.37ng/ml in model group and 61.68±11.69ng/ml and 411.24±15.74ng/ml in resveratrol group, respectively, 48 hours after provocation test（P0.01）. Conclusion Resveratrol can prevent and delay the occurrence of atherosclerosis by reducing the level of MMP-1 and MMP-9.

关 键 词：动脉硬化 白藜芦醇 基质金属蛋白酶 兔 

分 类 号：R544.1[医药卫生—心血管疾病]